[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-114-3-basic-medicine-038":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":37,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-114-3-基礎醫學-038","nurse-114-3-basic-medicine-038",114,3,38,"關於質子幫浦抑制劑（proton pump inhibitors, PPIs），下列敘述何者錯誤？",{"A":15,"B":16,"C":17,"D":18},"會明顯減少 clopidogrel 的抗血小板活性","不能使用在 aspirin 所造成的消化性潰瘍","應該在飯前 30～60 分鐘服用","可能會減少鈣的吸收，增加骨折的風險","B",null,[],"本題考點在於質子幫浦抑制劑(PPI)的臨床特性，為反向題，須挑出錯誤敘述。依適應症判斷，aspirin等NSAID造成的消化性潰瘍正是PPI的核心治療與預防用藥，故(B)敘述「不能使用在aspirin所造成的消化性潰瘍」為錯誤，選B。其餘皆正確：(A)PPI(尤其omeprazole)會抑制CYP2C19，減少clopidogrel活化而降低抗血小板效果；(C)PPI需在飯前30～60分鐘服用，以在餐後幫浦活化時達到血中濃度高峰；(D)長期使用會影響鈣吸收並增加骨折風險，皆屬正確描述。","PPI為前驅藥，需在酸性環境活化並不可逆結合H⁺\u002FK⁺-ATPase，故半衰期雖短、藥效卻長達24小時以上，這也是需飯前給藥的原因。與clopidogrel併用時，臨床偏好選CYP2C19影響較小的pantoprazole。長期併發症除骨質疏鬆外，還包括低鎂血症、維生素B12吸收下降與腸道感染風險上升，反映胃酸屏障被削弱的連鎖效應。",[25,28,31,33,35],{"term":26,"count":27},"CYP2C19",2,{"term":29,"count":30},"質子幫浦抑制劑",1,{"term":32,"count":30},"clopidogrel交互作用",{"term":34,"count":30},"NSAID潰瘍",{"term":36,"count":30},"飯前給藥",[38,42,47,52,57,61],{"webId":39,"stem":40,"number":41,"year":10,"session":11},"nurse-114-3-basic-medicine-039","下列何者為尿崩症（diabetes insipidus）之治療藥物？",39,{"webId":43,"stem":44,"number":45,"year":46,"session":27},"nurse-115-2-basic-medicine-035","下列關於 cimetidine 之敘述，何者錯誤？",35,115,{"webId":48,"stem":49,"number":50,"year":51,"session":30},"nurse-106-1-basic-medicine-079","立克次體與病毒相似的特性為何？",79,106,{"webId":53,"stem":54,"number":55,"year":56,"session":27},"nurse-107-2-basic-medicine-037","關於異生（dysplasia）的敘述，下列何者正確？",37,107,{"webId":58,"stem":59,"number":30,"year":60,"session":30},"nurse-109-1-basic-medicine-001","下列有關汗腺的敘述，何者正確？",109,{"webId":62,"stem":63,"number":45,"year":64,"session":30},"nurse-110-1-basic-medicine-035","堵塞性血栓血管炎（thromboangiitis obliterans）最常侵犯身體何處的血管？",110,"2026-09-04",1788510761268]