[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-114-3-basic-medicine-034":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-114-3-基礎醫學-034","nurse-114-3-basic-medicine-034",114,3,34,"用於治療巴金森氏症之藥物中，下列何者最不容易進入腦中產生作用？",{"A":15,"B":16,"C":17,"D":18},"pramipexole","carbidopa","benztropine","amantadine","B",null,[],"本題考點在於巴金森氏症用藥能否穿越血腦障壁進入中樞作用。Carbidopa為周邊多巴脫羧酶抑制劑,其設計特點正是不易通過血腦障壁,故僅在周邊抑制左多巴(levodopa)過早轉為多巴胺,減少周邊副作用並讓更多左多巴進入腦部,因此它最不容易進入腦中產生作用,選B。Pramipexole(A,多巴胺受體致效劑)、benztropine(C,抗膽鹼藥)、amantadine(D)皆須進入中樞才能發揮抗巴金森作用,能穿越血腦障壁,故非本題所選。","carbidopa『留在周邊』正是它的價值:與levodopa併用(如Sinemet)可讓levodopa在腦外不被浪費、降低噁心與姿勢性低血壓,並減少所需劑量。理解要點在於『藥效標的在腦內,但carbidopa的任務在腦外』,這種刻意不入腦的設計是本題的巧思所在。",[25,28,30,33],{"term":26,"count":27},"血腦障壁",7,{"term":16,"count":29},2,{"term":31,"count":32},"周邊多巴脫羧酶抑制",1,{"term":34,"count":32},"levodopa併用",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-114-3-basic-medicine-035","關於秋水仙素（colchicine），下列敘述何者錯誤？",35,{"webId":41,"stem":42,"number":43,"year":44,"session":29},"nurse-115-2-basic-medicine-031","藥物代謝過程中，經由加入葡萄糖醛酸（glucuronide）、硫酸、醋酸或胺基酸等之接合反應（conjugation reaction），其主要目的為何？",31,115,{"webId":46,"stem":47,"number":48,"year":49,"session":32},"nurse-106-1-basic-medicine-075","近年來，由於醫學發達，器官移植的可行性大為提高。下列何種病毒是可藉由輸血感染，尤其是在腎臟、骨髓移植後，接受免疫抑制治療時，更易再度活化？",75,106,{"webId":51,"stem":52,"number":53,"year":54,"session":29},"nurse-107-2-basic-medicine-033","下列何者不屬於典型慢性發炎的炎症浸潤細胞？",33,107,{"webId":56,"stem":57,"number":58,"year":59,"session":29},"nurse-108-2-basic-medicine-077","下列關於感染結核分枝桿菌（Mycobacterium tuberculosis）的敘述，何者正確？",77,108,{"webId":61,"stem":62,"number":43,"year":63,"session":32},"nurse-110-1-basic-medicine-031","腎臟對水的再吸收與下列何種離子最為相關？",110,"2026-09-04",1788510761230]