[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-114-3-basic-medicine-026":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-114-3-基礎醫學-026","nurse-114-3-basic-medicine-026",114,3,26,"家族腺瘤性瘜肉症（familial adenomatous polyposis）主要是因為那個基因產生突變所造成？",{"A":15,"B":16,"C":17,"D":18},"APC","WT1","MYC","BRCA1","A",null,[],"本題考點在於家族腺瘤性瘜肉症(FAP)的致病基因。FAP為體染色體顯性遺傳,因第5號染色體上的APC基因(腺瘤性瘜肉症大腸基因,屬腫瘤抑制基因)發生突變,使大腸出現成百上千顆腺瘤性瘜肉,若不切除幾乎必進展為大腸癌,故選A。WT1(B)與威爾姆氏腎母細胞瘤相關;MYC(C)為原癌基因,與伯基特氏淋巴瘤等相關;BRCA1(D)突變與遺傳性乳癌、卵巢癌相關,皆非FAP的致病基因,故錯。","APC是大腸癌『腺瘤─癌序列(adenoma-carcinoma sequence)』的起始關卡:APC失活啟動腺瘤,續而KRAS活化、TP53失活等逐步累積成癌。FAP屬『二次打擊』的腫瘤抑制基因遺傳病(先天帶一個突變、後天再失去另一個)。記憶配對:APC→大腸、WT1→腎母細胞瘤、BRCA→乳癌卵巢癌、RB→視網膜母細胞瘤。",[25,28,30,32],{"term":26,"count":27},"APC基因",1,{"term":29,"count":27},"家族腺瘤性瘜肉症",{"term":31,"count":27},"腺瘤─癌序列",{"term":33,"count":27},"腫瘤抑制基因",[35,39,45,50,55,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-114-3-basic-medicine-027","燒瓶狀潰瘍（flask-shaped ulcer）的最可能致病原因為何？",27,{"webId":40,"stem":41,"number":42,"year":43,"session":44},"nurse-115-2-basic-medicine-023","有關體染色體隱性（autosomal recessive）遺傳疾病的描述，下列何者錯誤？",23,115,2,{"webId":46,"stem":47,"number":48,"year":49,"session":27},"nurse-106-1-basic-medicine-067","大量產生腫瘤壞死因子-α（TNF-α）時不會引起下列何病症？",67,106,{"webId":51,"stem":52,"number":53,"year":54,"session":44},"nurse-107-2-basic-medicine-025","下列何種狀況有助於治療男性勃起（erection）障礙？",25,107,{"webId":56,"stem":57,"number":58,"year":59,"session":44},"nurse-108-2-basic-medicine-069","對於臨床症狀尚不明顯的布魯氏桿菌症（brucellosis），通常是以下列何種檢測來鑑定？",69,108,{"webId":61,"stem":62,"number":42,"year":63,"session":27},"nurse-110-1-basic-medicine-023","死亡後開始出現肌肉僵硬的現象，主要是由下列那一個原因造成？",110,"2026-09-04",1788510761152]