[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-114-2-basic-medicine-040":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":26},"nurse-114-2-基礎醫學-040","nurse-114-2-basic-medicine-040",114,2,40,"一位乳癌患者經化療藥物治療後，產生嚴重心臟毒性，最可能是使用下列何種抗癌藥物？",{"A":15,"B":16,"C":17,"D":18},"Bleomycin","Doxorubicin","Cyclophosphamide","Vinblastine","B",null,[],"本題考點在於化療藥物的器官毒性辨識。依抗癌藥毒性,Doxorubicin(小紅莓,anthracycline 類)具劑量累積性的心臟毒性,可造成擴張型心肌病變與心衰竭,故乳癌化療後出現嚴重心臟毒性最可能為此藥,選 B。A Bleomycin 主要毒性為肺纖維化;C Cyclophosphamide 高劑量可致出血性膀胱炎;D Vinblastine 主要為骨髓抑制與神經毒性。故正解為 B。","機轉:anthracycline 產生自由基並干擾拓樸異構酶 II,對心肌造成累積性傷害,故有終生總劑量上限,並可用 dexrazoxane 降低心毒性,治療前後須監測左心室射出分率。毒性口訣:小紅莓傷心、bleomycin 傷肺、cyclophosphamide 傷膀胱、cisplatin 傷腎與耳。",[25,27,29,31],{"term":16,"count":26},1,{"term":28,"count":26},"anthracycline 類",{"term":30,"count":26},"累積性心臟毒性",{"term":32,"count":26},"自由基傷害",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-114-2-basic-medicine-041","外科手術器材如帶有塑膠材質，下列何者是最適合的消毒法？",41,{"webId":39,"stem":40,"number":41,"year":42,"session":26},"nurse-115-1-basic-medicine-037","下列何種抗組織胺（antihistamines）較不易有昏睡之副作用？",37,115,{"webId":44,"stem":45,"number":46,"year":47,"session":26},"nurse-106-1-basic-medicine-031","胃腺之何種細胞負責分泌胃泌素（gastrin）？",31,106,{"webId":49,"stem":50,"number":51,"year":52,"session":26},"nurse-107-1-basic-medicine-069","下列何者不屬於第三型過敏反應（Type III hypersensitivity）引起之疾病或反應？",69,107,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-108-2-basic-medicine-033","下列何種疾病最不常以肉芽腫性發炎來呈現？",33,108,{"webId":59,"stem":60,"number":61,"year":62,"session":11},"nurse-109-2-basic-medicine-067","臨床上以免疫學方法快速診斷隱球菌（Cryptococcus neoformans）引起之感染，通常是直接偵測下列何者？",67,109,"2026-09-04",1788510758870]