[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-114-2-basic-medicine-031":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-114-2-基礎醫學-031","nurse-114-2-basic-medicine-031",114,2,31,"巨環類抗生素（macrolides）最不易引起下列何種副作用？",{"A":15,"B":16,"C":17,"D":18},"腸胃不適","黃疸","耳毒性","癲癇","D",null,[],"本題考點在於巨環類抗生素的副作用譜。依巨環類(macrolides,如 erythromycin)藥理特性,其常見副作用包括腸胃蠕動增強造成的腸胃不適、膽汁鬱積性黃疸(尤 estolate 鹽)、以及高劑量時的可逆性耳毒性;而癲癇並非其典型副作用,故最不易引起者為 D,選 D。A 腸胃不適因刺激 motilin 受體常見;B 黃疸可見於肝毒性反應;C 耳毒性在高劑量或腎功能不良時可能發生。故正解為 D。","藥理延伸:macrolides 是 motilin 受體致效劑,故 erythromycin 有促腸胃蠕動作用(臨床反用於胃輕癱)。另需注意其抑制 CYP3A4 造成藥物交互作用,並可延長 QT 間期。癲癇則較常與 imipenem、高劑量 β-lactam 或 fluoroquinolone 相關。",[25,27,29,32],{"term":26,"count":11},"巨環類抗生素",{"term":28,"count":11},"motilin 受體",{"term":30,"count":31},"膽汁鬱積性黃疸",1,{"term":33,"count":31},"QT 延長",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-114-2-basic-medicine-032","下列何者不屬於毒蕈鹼拮抗劑（muscarinic antagonist）的臨床適應症？",32,{"webId":40,"stem":41,"number":42,"year":43,"session":31},"nurse-115-1-basic-medicine-028","有關性傳播疾病（sexually transmitted infections, STIs）的敘述，下列何者錯誤？",28,115,{"webId":45,"stem":46,"number":47,"year":48,"session":31},"nurse-106-1-basic-medicine-022","下列何者藉由糖質新生作用增高血糖濃度？",22,106,{"webId":50,"stem":51,"number":52,"year":53,"session":31},"nurse-107-1-basic-medicine-060","下列藥物何者不適用於鼻炎（rhinitis）的治療用藥？",60,107,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-108-2-basic-medicine-024","一位 50 歲女性有低血鈣、高血磷與低尿磷等症狀，注射副甲狀腺素（PTH）治療會增加尿液中 cAMP 的濃度，此女士可能罹患下列何種疾病？",24,108,{"webId":60,"stem":61,"number":62,"year":63,"session":11},"nurse-109-2-basic-medicine-058","Amiodarone為治療心室心搏過速，合併左心室功能受損之首選用藥，下列何者不是長期使用此藥後的副作用？",58,109,"2026-09-04",1788510758780]