[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-114-1-basic-medicine-040":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-114-1-基礎醫學-040","nurse-114-1-basic-medicine-040",114,1,40,"使用化學治療藥於癌症病患，有時會給與amifostine，試問amifostine有何藥理作用？",{"A":15,"B":16,"C":17,"D":18},"保護正常細胞組織，避免細胞損傷","增強抗癌藥穿透血腦障壁，進入中樞神經系統","減少腫瘤組織周邊血液的asparagine含量","增強病人的免疫系統功能","A",null,[],"本題考點在於化療輔助藥 amifostine 的藥理作用。依藥理，amifostine 為含硫醇的細胞保護劑，在正常組織經鹼性磷酸酶活化為活性代謝物，清除化療與放療產生的自由基，選擇性保護正常細胞、減少毒性，故選 A。B 錯誤，其與增強穿透血腦障壁無關；C 描述的是 asparaginase 對 asparagine 的清除；D 錯誤，它並非免疫增強劑，均非 amifostine 的作用。","amifostine 之所以選擇性保護正常組織，是因正常組織鹼性磷酸酶活性較高、活化較充分，且腫瘤微環境偏酸、血流差而活化受限。臨床用於降低 cisplatin 腎毒性與放療口乾。記憶要點：amifostine＝自由基清道夫，護正常細胞不護腫瘤。",[25,28,30,32],{"term":26,"count":27},"鹼性磷酸酶",2,{"term":29,"count":11},"amifostine",{"term":31,"count":11},"細胞保護劑",{"term":33,"count":11},"自由基清除",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-114-1-basic-medicine-041","細菌間遺傳物質移轉有不同方式，其中噬菌體（phage）是藉由下列何種方式進行？",41,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-114-3-basic-medicine-037","下列藥物中，何者可活化中樞神經 α2 受體，進而減少交感神經活性而達到降血壓效果？",37,3,{"webId":45,"stem":46,"number":47,"year":48,"session":27},"nurse-115-2-basic-medicine-031","藥物代謝過程中，經由加入葡萄糖醛酸（glucuronide）、硫酸、醋酸或胺基酸等之接合反應（conjugation reaction），其主要目的為何？",31,115,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-107-1-basic-medicine-019","當迷走神經興奮時，對心臟的影響下列何者正確？",19,107,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-108-1-basic-medicine-063","關於腸泌素類似物（incretin minetics）的敘述，下列何者錯誤？",63,108,{"webId":60,"stem":61,"number":62,"year":63,"session":27},"nurse-109-2-basic-medicine-017","一莫耳葡萄糖（即180克）溶解於1公升水中所產生的滲透壓濃度為多少Osmol\u002FL？",17,109,"2026-09-04",1788510756582]