[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-114-1-basic-medicine-039":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-114-1-基礎醫學-039","nurse-114-1-basic-medicine-039",114,1,39,"下列有關doxorubicin的描述，何者錯誤？",{"A":15,"B":16,"C":17,"D":18},"可治療急性淋巴球性白血病","可治療肉瘤","具有劑量依賴性的心臟毒性","可抑制topoisomerase I 活性","D",null,[],"本題考點在於 doxorubicin 的藥理特性，本題為反向題，要找出錯誤敘述。依藥理，doxorubicin 屬蒽環類抗癌藥，其作用機轉是嵌入 DNA 並抑制「topoisomerase II」（非 topoisomerase I）並產生自由基，故 D 所述抑制 topoisomerase I 為錯誤，選 D。A 正確，可用於急性淋巴球性白血病；B 正確，對多種肉瘤有效；C 正確，其標誌性副作用為劑量依賴、累積性的心臟毒性。","抑制 topoisomerase I 的是 irinotecan、topotecan 一類。doxorubicin 心毒性源於自由基造成心肌損傷，可用累積劑量上限與 dexrazoxane 保護。記憶對比：蒽環類（-rubicin）打 topo II、camptothecin 衍生物打 topo I；看到紅色藥、心臟毒即想 doxorubicin。",[25,27,29,31],{"term":26,"count":11},"doxorubicin",{"term":28,"count":11},"topoisomerase II",{"term":30,"count":11},"蒽環類",{"term":32,"count":11},"心臟毒性",[34,38,43,49,54,59],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-114-1-basic-medicine-040","使用化學治療藥於癌症病患，有時會給與amifostine，試問amifostine有何藥理作用？",40,{"webId":39,"stem":40,"number":41,"year":10,"session":42},"nurse-114-3-basic-medicine-036","下列利尿劑（diuretics）中，何者為醛固酮受體（aldosterone receptor）拮抗劑，常用於治療心衰竭？",36,3,{"webId":44,"stem":45,"number":46,"year":47,"session":48},"nurse-115-2-basic-medicine-030","有關發生在骨頭之轉移性腫瘤（metastatic tumors），下列敘述何者錯誤？",30,115,2,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-107-1-basic-medicine-018","骨骼肌收縮時的鈣離子是從那種鈣通道釋放出來？",18,107,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-108-1-basic-medicine-062","下列何種藥物，是藉由活化氯離子通道而增加腸道液體的釋放，用於治療慢性便祕？",62,108,{"webId":60,"stem":61,"number":62,"year":63,"session":48},"nurse-109-2-basic-medicine-016","交感神經中的大內臟神經（greater splanchnic nerve）其節前神經纖維來自下列何者？",16,109,"2026-09-04",1788510756578]