[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-114-1-basic-medicine-038":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-114-1-基礎醫學-038","nurse-114-1-basic-medicine-038",114,1,38,"下列那一個藥物最適合用來治療變形性骨炎（Paget disease）？",{"A":15,"B":16,"C":17,"D":18},"zoledronic acid","denosumab","teriparatide","romosozumab","A",null,[],"本題考點在於變形性骨炎（Paget 氏病）的藥物治療首選。依藥理，此病特徵為蝕骨細胞活性異常亢進導致骨代謝過快，雙磷酸鹽類的 zoledronic acid 能抑制蝕骨細胞、降低骨轉換，是治療首選，故選 A。B denosumab 為抗 RANKL 單株抗體，主要用於骨質疏鬆；C teriparatide 為副甲狀腺素類似物、促骨生成，反而可能刺激異常骨轉換；D romosozumab 抗硬骨素、用於骨鬆，皆非 Paget 氏病的標準首選。","Paget 氏病是局部骨骼重塑失控，先過度吸收再雜亂生成，造成骨骼變形、疼痛與病理性骨折。雙磷酸鹽附著於骨表面、被蝕骨細胞吞入後誘其凋亡，可快速壓下高骨轉換。記憶要點：骨轉換太快就用雙磷酸鹽踩煞車，靜脈單劑 zoledronic acid 效果持久。",[25,28,30,31],{"term":26,"count":27},"雙磷酸鹽",2,{"term":29,"count":11},"變形性骨炎",{"term":15,"count":11},{"term":32,"count":11},"蝕骨細胞",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-114-1-basic-medicine-039","下列有關doxorubicin的描述，何者錯誤？",39,{"webId":39,"stem":40,"number":41,"year":10,"session":42},"nurse-114-3-basic-medicine-035","關於秋水仙素（colchicine），下列敘述何者錯誤？",35,3,{"webId":44,"stem":45,"number":46,"year":47,"session":27},"nurse-115-2-basic-medicine-029","第二型糖尿病的致病機轉，與下列何者最不相關？",29,115,{"webId":49,"stem":50,"number":51,"year":52,"session":11},"nurse-107-1-basic-medicine-017","有關脂質（lipid）與脂肪（fat）的敘述，下列何者正確？",17,107,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-108-1-basic-medicine-061","血管緊縮素轉換酶抑制劑（angiotensin converting enzyme inhibitor, ACEI）的降血壓作用機制，包括下列那一項？",61,108,{"webId":59,"stem":60,"number":61,"year":62,"session":27},"nurse-109-2-basic-medicine-015","從脊髓圓錐（conus medullaris）向下延伸，下列何者連結尾骨，可用來幫忙固定脊髓？",15,109,"2026-09-04",1788510756565]