[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-114-1-basic-medicine-030":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-114-1-基礎醫學-030","nurse-114-1-basic-medicine-030",114,1,30,"庫賈氏病（Creutzfeldt-Jakob disease）最典型的病理變化為下列何者？",{"A":15,"B":16,"C":17,"D":18},"脫髓鞘斑塊","腦膿瘍","中腦黑質退化","大腦海綿狀轉化","D",null,[],"本題考點在於庫賈氏病（CJD）的典型神經病理變化。依病理學，CJD 屬普利昂蛋白（prion）疾病，異常摺疊的普利昂蛋白堆積導致神經元空泡化，鏡下呈現大腦灰質的「海綿狀轉化」，故選 D。A 脫髓鞘斑塊是多發性硬化症的特徵；B 腦膿瘍為細菌等化膿性感染所致的局部積膿；C 中腦黑質退化是帕金森氏症的病變部位，皆與 CJD 的海綿狀變性無關。","普利昂為可自我複製的錯誤摺疊蛋白，不含核酸，故一般消毒難以去活性。CJD 臨床特徵為快速進行的失智、肌陣攣與腦電圖週期性放電，病程通常數月內致命。記憶口訣：海綿腦（spongiform）＝普利昂病，同類尚有庫魯病與變異型 CJD（與狂牛症相關）。",[25,28,31,33],{"term":26,"count":27},"海綿狀腦病變",4,{"term":29,"count":30},"庫賈氏病",2,{"term":32,"count":11},"普利昂蛋白",{"term":34,"count":11},"神經元空泡化",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-114-1-basic-medicine-031","下列何種藥物不能抑制乙醯膽鹼酯酶（acetylcholinesterase）？",31,{"webId":41,"stem":42,"number":43,"year":10,"session":44},"nurse-114-3-basic-medicine-027","燒瓶狀潰瘍（flask-shaped ulcer）的最可能致病原因為何？",27,3,{"webId":46,"stem":47,"number":48,"year":49,"session":30},"nurse-115-2-basic-medicine-021","一名 20 歲男性，由於車禍導致腿部骨折，以石膏固定傷肢。在骨折癒合期間，肌肉量會減少。這是下列何種類型的細胞適應性反應？",21,115,{"webId":51,"stem":52,"number":53,"year":54,"session":11},"nurse-107-1-basic-medicine-009","主動脈體透過下列何者傳遞血液中 O 2 含量變化的訊息？",9,107,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-108-1-basic-medicine-053","下列何者不是治療骨質疏鬆症的藥物？",53,108,{"webId":61,"stem":62,"number":63,"year":64,"session":30},"nurse-109-2-basic-medicine-007","下列何者的血液供應不源自腹腔動脈幹（celiac trunk）的分枝？",7,109,"2026-09-04",1788510756484]