[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-113-3-basic-medicine-045":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-113-3-基礎醫學-045","nurse-113-3-basic-medicine-045",113,3,45,"法蘭西氏土倫桿菌（Francisella tularensis）可以在巨噬細胞內存活一段時間的主要原因為何？",{"A":15,"B":16,"C":17,"D":18},"抑制吞噬體-溶酶體（phagosome-lysosome）的融合","具有抗氧化的能力（anti-oxidants）","不具脂質莢膜（lipid capsule）","具有內毒素（endotoxin）","A",null,[],"本題考點在於胞內菌逃避吞噬殺菌的機轉。巨噬細胞殺菌仰賴吞噬體與溶酶體融合、以水解酶與活性氧殺死病原。法蘭西氏土倫桿菌（Francisella tularensis）能在巨噬細胞內存活，主要靠抑制吞噬體與溶酶體的融合，甚至逃逸至細胞質增殖，藉此躲過溶酶體酶的分解，選 A。選項 B 抗氧化能力雖可對抗活性氧、屬輔助機轉，但並非其在巨噬細胞內存活的「主要」原因；選項 C「不具脂質莢膜」敘述本身與胞內存活無因果，且方向錯誤；選項 D 內毒素是革蘭氏陰性菌外膜 LPS，主導的是發炎與敗血反應，並非幫助菌在吞噬細胞內存活的機制。","胞內菌逃殺常見三招：抑制吞噬體—溶酶體融合（如結核桿菌、Francisella）、逃逸到細胞質（如 Listeria）、耐受吞噬體酸性環境（如 Coxiella）。Francisella 逃逸機制與其毒力島基因有關，屬 A 類生物恐怖病原、感染劑量極低，是防疫考點。",[25,28,31,33],{"term":26,"count":27},"Francisella tularensis",2,{"term":29,"count":30},"吞噬體—溶酶體融合",1,{"term":32,"count":30},"胞內菌逃避機轉",{"term":34,"count":30},"巨噬細胞殺菌",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-113-3-basic-medicine-046","肝炎病毒中，那一種病毒需要 B 型肝炎病毒同時感染，才能幫助它複製繁殖？",46,{"webId":41,"stem":42,"number":43,"year":44,"session":27},"nurse-114-2-basic-medicine-042","下列何者為正確的五大主要類型免疫球蛋白（immunoglobulin）？",42,114,{"webId":46,"stem":47,"number":48,"year":49,"session":30},"nurse-115-1-basic-medicine-036","有關吸入性麻醉劑的最低肺泡濃度（minimum alveolar concentration, MAC）之敘述，下列何者最不適當？",36,115,{"webId":51,"stem":52,"number":53,"year":54,"session":27},"nurse-106-2-basic-medicine-054","下列用於 sleep disorders 之藥物，何者可明顯縮短入睡時間及減少睡眠中醒來次數，但會造成病人有白天中樞抑制（daytime sedation）之副作用？",54,106,{"webId":56,"stem":57,"number":58,"year":59,"session":30},"nurse-108-1-basic-medicine-018","下列何者是肌細胞在初期收縮時的主要能量來源？",18,108,{"webId":61,"stem":62,"number":63,"year":64,"session":30},"nurse-109-1-basic-medicine-052","下列何種藥物可抑制 tumor tyrosine kinase 活性，因而可用於 chronic myeloid leukemia 及 gastrointestinal stromal tumor？",52,109,"2026-09-04",1788510751875]