[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-113-3-basic-medicine-040":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-113-3-基礎醫學-040","nurse-113-3-basic-medicine-040",113,3,40,"下列那一個藥物屬於 topoisomerase I 抑制劑？",{"A":15,"B":16,"C":17,"D":18},"vinblastine","paclitaxel","irinotecan","azacitidine","C",null,[],"本題考點在於抗癌藥物依作用標的的機轉分類，須辨識 topoisomerase I（拓樸異構酶 I）抑制劑。拓樸異構酶 I 負責切開單股 DNA 以釋放複製時的超螺旋張力，其抑制劑會穩定「酵素—DNA」切割複合體、造成 DNA 斷裂。irinotecan 為喜樹鹼衍生物，正是典型 topoisomerase I 抑制劑，選 C。vinblastine 為長春花生物鹼，結合 tubulin 抑制微管聚合、阻止紡錘體形成；paclitaxel 為紫杉醇，機轉相反、穩定微管使其無法解聚，兩者皆作用於微管而非拓樸酶；azacitidine 為胞嘧啶核苷類似物、屬去甲基化抗代謝藥，作用於 DNA 甲基化。三者均非拓樸異構酶 I 抑制劑。","拓樸異構酶抑制劑分兩支：topo I 抑制劑為喜樹鹼類（irinotecan、topotecan，字尾 -tecan）；topo II 抑制劑為 etoposide、doxorubicin。微管藥則分「抑制聚合」的長春花類（vin-）與「穩定不解聚」的紫杉醇類（taxel），兩者殊途同歸都卡住有絲分裂。",[25,28,30,32],{"term":26,"count":27},"拓樸異構酶 I 抑制劑",1,{"term":29,"count":27},"irinotecan 喜樹鹼",{"term":31,"count":27},"微管藥物",{"term":33,"count":27},"抗癌藥機轉分類",[35,39,45,50,55,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-113-3-basic-medicine-041","為了降低抗藥性細菌的發生率，應該採取下列那一種措施？",41,{"webId":40,"stem":41,"number":42,"year":43,"session":44},"nurse-114-2-basic-medicine-037","下列利尿劑中，何者在頻繁及高劑量使用下易產生耳毒性（ototoxicity）副作用？",37,114,2,{"webId":46,"stem":47,"number":48,"year":49,"session":27},"nurse-115-1-basic-medicine-031","下列何者可治療腹瀉及具有腸道抗菌效果，並可預防旅行腹瀉（traveler’s diarrhea）？",31,115,{"webId":51,"stem":52,"number":53,"year":54,"session":44},"nurse-106-2-basic-medicine-049","林先生因誤食農藥巴拉松（parathion）而被送醫急救，當抵達急診室時，林先生已出現意識模糊、瞳孔縮小、全身輕微抽搐等症狀，此時，進行下列何種處置最適當？",49,106,{"webId":56,"stem":57,"number":58,"year":59,"session":27},"nurse-108-1-basic-medicine-013","肺部的那一種細胞，主要負責分泌表面張力劑(surfactant)，可以降低肺泡內的表面張力，避免肺泡塌陷？",13,108,{"webId":61,"stem":62,"number":63,"year":64,"session":27},"nurse-109-1-basic-medicine-047","重症肌無力（myasthenia gravis）的主要病變是發生在何處？",47,109,"2026-09-04",1788510751829]