[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-113-2-basic-medicine-036":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-113-2-基礎醫學-036","nurse-113-2-basic-medicine-036",113,2,36,"Clopidogrel 抑制血小板凝集的作用機制為何？",{"A":15,"B":16,"C":17,"D":18},"不可逆性地抑制第一型環氧酶（cyclooxygenase 1）","不可逆性地抑制凝血因子 Xa","不可逆性地抑制 P 2 Y 12 ADP 受體","抑制血栓素 A 2 （TXA 2 ）受體","C",null,[],"本題考點在於抗血小板藥 clopidogrel 的作用機轉。依藥理學，clopidogrel 為前驅藥，經肝臟 CYP2C19 活化後，不可逆地抑制血小板上的 P2Y12 ADP 受體，阻斷 ADP 引發的 GPIIb\u002FIIIa 活化與血小板凝集，故選 C。A 不可逆抑制環氧酶第一型（COX-1）是 aspirin 的機轉。B 抑制凝血因子 Xa 是 rivaroxaban 等的機轉。D 抑制血栓素 A2 受體並非 clopidogrel 的作用點。","抗血小板三路對照：aspirin（不可逆抑 COX-1，減 TXA2）、P2Y12 抑制劑（clopidogrel、prasugrel、ticagrelor）、GPIIb\u002FIIIa 拮抗劑（abciximab）。clopidogrel 依賴 CYP2C19 活化，慢代謝型或併用 omeprazole 可能療效打折，故臨床有基因型考量。急性冠心症常用 aspirin 加 P2Y12 的雙抗療法。",[25,27,30,32],{"term":26,"count":11},"clopidogrel",{"term":28,"count":29},"P2Y12 ADP 受體",1,{"term":31,"count":29},"不可逆抑制",{"term":33,"count":29},"抗血小板機轉分類",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-113-2-basic-medicine-037","下列何者屬於抑制腸胃蠕動的藥物（antimotility agents），用於治療嚴重腹瀉？",37,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-114-1-basic-medicine-033","使用局部麻醉劑時常與腎上腺素合用，其目的為何？",33,114,{"webId":45,"stem":46,"number":47,"year":43,"session":48},"nurse-114-3-basic-medicine-027","燒瓶狀潰瘍（flask-shaped ulcer）的最可能致病原因為何？",27,3,{"webId":50,"stem":51,"number":52,"year":53,"session":29},"nurse-106-1-basic-medicine-075","近年來，由於醫學發達，器官移植的可行性大為提高。下列何種病毒是可藉由輸血感染，尤其是在腎臟、骨髓移植後，接受免疫抑制治療時，更易再度活化？",75,106,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-107-2-basic-medicine-039","吸入下列何者最有可能導致間皮瘤（mesothelioma）？",39,107,{"webId":60,"stem":61,"number":62,"year":63,"session":11},"nurse-108-2-basic-medicine-073","與未成熟的樹突細胞比較，下列何者是活化後的樹突細胞的主要免疫作用？",73,108,"2026-09-04",1788510754200]