[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-113-2-basic-medicine-024":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-113-2-基礎醫學-024","nurse-113-2-basic-medicine-024",113,2,24,"Familial breast and ovarian carcinoma syndrome 的突變基因為何？",{"A":15,"B":16,"C":17,"D":18},"PTEN","NF1","PTCH","BRCA1 and BRCA2","D",null,[],"本題考點在於遺傳性乳癌卵巢癌症候群的致病基因。依腫瘤遺傳學，家族性乳癌與卵巢癌症候群（familial breast and ovarian carcinoma syndrome）由 BRCA1 與 BRCA2 抑癌基因的胚系突變造成，兩者參與 DNA 雙股斷裂的同源重組修復，失能後突變累積致癌，故選 D。A PTEN 對應 Cowden 症候群。B NF1 對應第一型神經纖維瘤病。C PTCH 對應 Gorlin（基底細胞痣）症候群，皆非本症候群的主要突變基因。","BRCA1\u002F2 屬「守護基因型」抑癌基因，走同源重組修復（HRR）。此缺陷可被 PARP 抑制劑以合成致死策略打擊，是精準醫療經典。BRCA1 亦增卵巢癌與三陰性乳癌風險。記憶配對：PTEN-Cowden、NF1-神經纖維瘤、PTCH-Gorlin、RB1-視網膜母細胞瘤、APC-家族性大腸息肉症。",[25,27,30,32],{"term":26,"count":11},"抑癌基因",{"term":28,"count":29},"BRCA1\u002FBRCA2",1,{"term":31,"count":29},"遺傳性乳癌卵巢癌症候群",{"term":33,"count":29},"同源重組修復",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-113-2-basic-medicine-025","下列何者非屬石棉相關疾病（asbestos-related diseases）？",25,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-114-1-basic-medicine-021","有關急性發炎反應（acute inflammation）的敘述，下列何者正確？",21,114,{"webId":45,"stem":46,"number":47,"year":43,"session":48},"nurse-114-3-basic-medicine-015","有關甲狀腺素（thyroxine, T4）和三碘甲狀腺素（T3）的比較，下列何者正確？",15,3,{"webId":50,"stem":51,"number":52,"year":53,"session":29},"nurse-106-1-basic-medicine-063","下列青黴素類（penicillins）抗生素中，何者因為不易被葡萄球菌產生之 penicillinase 破壞，所以主要用於治療葡萄球菌造成之感染？",63,106,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-107-2-basic-medicine-027","有關扁桃體的敘述，下列何者正確？",27,107,{"webId":60,"stem":61,"number":62,"year":63,"session":11},"nurse-108-2-basic-medicine-061","下列何種藥物可使鼻黏膜上小動脈收縮，作為鼻充血腫脹解除劑，用於治療鼻炎？",61,108,"2026-09-04",1788510754079]