[{"data":1,"prerenderedAt":67},["ShallowReactive",2],{"q-nurse-113-1-basic-medicine-042":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":66},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-113-1-基礎醫學-042","nurse-113-1-basic-medicine-042",113,1,42,"下列那個酵素主要負責B細胞的體細胞超突變（somatic hypermutation）？",{"A":15,"B":16,"C":17,"D":18},"RAG1（recombination-activating gene 1）","RAG2（recombination-activating gene 2）","TdT（terminal deoxynucleotidyl transferase）","AID（activation-induced cytidine deaminase）","D",null,[],"本題考點在於負責 B 細胞體細胞超突變的酵素。依免疫學，AID（活化誘導胞苷去胺酶）在生發中心使免疫球蛋白可變區基因產生點突變（體細胞超突變）並啟動類別轉換，以提升抗體親和力，故選 D。A RAG1、B RAG2 負責早期的 V(D)J 基因重組；C TdT 於重組時隨機加入核苷酸增加多樣性，皆屬淋巴球發育早期的機制，非成熟 B 細胞的超突變，故錯。","抗體多樣性分兩階段：發育期由 RAG1\u002F2＋TdT 做 V(D)J 重組（骨髓\u002F胸腺，抗原非依賴）；成熟後在生發中心由 AID 驅動體細胞超突變（親和力成熟）與類別轉換重組（CSR，IgM→IgG\u002FA\u002FE）。AID 缺陷會造成高 IgM 症候群。記憶：RAG＝出廠組裝，AID＝上戰場後微調升級。",[25,28,30,32,34],{"term":26,"count":27},"親和力成熟",3,{"term":29,"count":11},"AID",{"term":31,"count":11},"體細胞超突變",{"term":33,"count":11},"生發中心",{"term":35,"count":11},"類別轉換",[37,41,45,51,56,61],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-113-1-basic-medicine-043","有關抗體的敘述，下列何者錯誤？",43,{"webId":42,"stem":43,"number":44,"year":10,"session":27},"nurse-113-3-basic-medicine-039","下列抗癌藥物中，何者不屬於烷基化藥物（alkylating agents）？",39,{"webId":46,"stem":47,"number":48,"year":49,"session":50},"nurse-114-2-basic-medicine-033","下列降血壓藥物中，何者為腎素抑制劑（renin inhibitor）？",33,114,2,{"webId":52,"stem":53,"number":54,"year":55,"session":11},"nurse-106-1-basic-medicine-031","胃腺之何種細胞負責分泌胃泌素（gastrin）？",31,106,{"webId":57,"stem":58,"number":59,"year":60,"session":11},"nurse-107-1-basic-medicine-075","威脅生命的擴散性念珠菌症（disseminated candidiasis）主要發生在何種病人？",75,107,{"webId":62,"stem":63,"number":64,"year":65,"session":50},"nurse-108-2-basic-medicine-029","下列何者可產生表面活性劑（surfactant）？",29,108,"2026-09-04",1788510749724]