[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-113-1-basic-medicine-035":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-113-1-基礎醫學-035","nurse-113-1-basic-medicine-035",113,1,35,"Fexofenadine較不具鎮靜安眠作用，原因為何？",{"A":15,"B":16,"C":17,"D":18},"較難通過血腦障壁","對H1受體的選擇性增加","抑制中樞GABA受體","體內半衰期短","A",null,[],"本題考點在於 fexofenadine 較無鎮靜作用的原因。依藥理學，fexofenadine 為第二代 H1 抗組織胺，極性較高、且為 P-醣蛋白受質，較難通過血腦障壁進入中樞，因此中樞 H1 拮抗作用弱、嗜睡副作用小，故選 A。B 對 H1 選擇性提高不是無鎮靜的主因（第一代同樣選擇性高卻嗜睡）；C 抑制中樞 GABA 反而會鎮靜；D 半衰期短與鎮靜無直接關係，故錯。","第一代抗組織胺（diphenhydramine、chlorpheniramine）脂溶性高、易入腦阻斷中樞 H1 而嗜睡；第二代（fexofenadine、loratadine、cetirizine）親水且受 P-gp 外排，血腦障壁通透差，故較不鎮靜、適合白天用。記憶：能不能過 BBB＝會不會想睡，是新舊抗組織胺的分水嶺。",[25,28,30,32],{"term":26,"count":27},"血腦障壁",7,{"term":29,"count":11},"fexofenadine",{"term":31,"count":11},"第二代抗組織胺",{"term":33,"count":11},"P-醣蛋白",[35,39,44,50,55,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-113-1-basic-medicine-036","口服抗凝血劑warfarin中毒出血時，應如何救治最好？",36,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-113-3-basic-medicine-032","下列安眠藥中，何者能活化 melatonin receptor（褪黑激素受體）？",32,3,{"webId":45,"stem":46,"number":47,"year":48,"session":49},"nurse-114-2-basic-medicine-026","3 歲男性，右側睪丸有一個腫瘤，抽血發現血清中的甲型胎兒蛋白（α -fetoprotein）異常升高，他的睪丸腫瘤最可能是那一種？",26,114,2,{"webId":51,"stem":52,"number":53,"year":54,"session":11},"nurse-106-1-basic-medicine-024","下列何時期，血液中雌激素與黃體素濃度接近懷孕初期之濃度？",24,106,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-107-1-basic-medicine-068","有關抗體的敘述，下列何者錯誤？",68,107,{"webId":61,"stem":62,"number":63,"year":64,"session":49},"nurse-108-2-basic-medicine-022","包圍周邊神經軸突的髓鞘（myelin sheath），主要組成為何？",22,108,"2026-09-04",1788510749671]