[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-112-3-basic-medicine-039":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-112-3-基礎醫學-039","nurse-112-3-basic-medicine-039",112,3,39,"下列化療藥物中，何者主要使用於腦瘤治療？",{"A":15,"B":16,"C":17,"D":18},"Ifosfamide","Cisplatin","Carmustine","Dacarbazine","C",null,[],"本題考點在於化療藥物的組織分布特性。腦瘤治療的關鍵是藥物須能穿透血腦障壁，Carmustine（BCNU）屬亞硝基脲類（nitrosourea），具高度脂溶性可通過血腦障壁進入中樞神經，故常用於腦瘤，選 C。A 的 Ifosfamide 為烷化劑，主要用於肉瘤、睪丸癌等。B 的 Cisplatin 為鉑類化合物，用於肺癌、卵巢癌、膀胱癌等實體腫瘤。D 的 Dacarbazine 主要用於黑色素瘤與何杰金氏淋巴瘤。三者穿透中樞能力不足或適應症不同，故不選。","血腦障壁只讓高脂溶性、低分子量藥物通過，這正是多數化療藥對腦瘤無效的原因。Nitrosourea 類（carmustine、lomustine）因高脂溶性成為少數可治腦瘤的化療藥；carmustine 也做成植入晶片（Gliadel wafer）直接置於腫瘤切除腔。記憶：想到腦瘤化療就聯想 nitrosourea 的脂溶穿透力。",[25,28,31,33],{"term":26,"count":27},"血腦障壁穿透",2,{"term":29,"count":30},"Carmustine亞硝基脲",1,{"term":32,"count":30},"脂溶性",{"term":34,"count":30},"腦瘤化療",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-112-3-basic-medicine-040","長期使用免疫抑制劑 Cyclosporine 治療自體免疫疾病，可能引發下列何種副作用？",40,{"webId":41,"stem":42,"number":43,"year":44,"session":27},"nurse-113-2-basic-medicine-036","Clopidogrel 抑制血小板凝集的作用機制為何？",36,113,{"webId":46,"stem":47,"number":48,"year":49,"session":30},"nurse-114-1-basic-medicine-030","庫賈氏病（Creutzfeldt-Jakob disease）最典型的病理變化為下列何者？",30,114,{"webId":51,"stem":52,"number":53,"year":54,"session":27},"nurse-115-2-basic-medicine-028","下列何者為腎病症候群（nephrotic syndrome）最主要的變化？",28,115,{"webId":56,"stem":57,"number":58,"year":59,"session":30},"nurse-107-1-basic-medicine-022","終板電位（end-plate potential）屬於下列何種電位？",22,107,{"webId":61,"stem":62,"number":63,"year":64,"session":30},"nurse-108-1-basic-medicine-056","下列何者為 pilocarpine 的拮抗劑？",56,108,"2026-09-04",1788510744226]