[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-112-3-basic-medicine-035":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-112-3-基礎醫學-035","nurse-112-3-basic-medicine-035",112,3,35,"非類固醇抗發炎藥物（NSAIDs）可以抑制下列何種酵素之活性，減少前列腺素生成，而產生解熱、鎮痛，以及抗發炎效果？",{"A":15,"B":16,"C":17,"D":18},"cyclooxygenase","angiotensin converting enzyme","HMG CoA reductase","xanthine oxidase","A",null,[],"本題考點在於 NSAIDs 的作用機轉。NSAIDs 之所以能解熱、鎮痛、抗發炎，是因為它抑制環氧化酶（cyclooxygenase, COX），阻斷花生四烯酸轉變為前列腺素的步驟，前列腺素減少後發炎、疼痛與發燒反應隨之下降，故選 A。B 的血管收縮素轉化酶（ACE）是 ACE 抑制劑降血壓的標的，與前列腺素無關。C 的 HMG-CoA 還原酶是 statin 類降血脂藥抑制的膽固醇合成限速酵素。D 的黃嘌呤氧化酶是 allopurinol 治療痛風、降尿酸的作用標的。三者皆非前列腺素合成路徑上的酵素，故不選。","COX 分為 COX-1（生理性，維持胃黏膜、腎血流、血小板功能）與 COX-2（發炎誘導型）。傳統非選擇性 NSAIDs 同時抑制兩者，故止痛的同時傷胃、傷腎；選擇性 COX-2 抑制劑（如 celecoxib）胃腸副作用較少但增加心血管風險。記憶對比：COX→前列腺素、ACE→血管收縮素II、HMG-CoA還原酶→膽固醇、黃嘌呤氧化酶→尿酸，四個酵素各對應一類常考藥物。",[25,27,30,33],{"term":26,"count":11},"花生四烯酸代謝",{"term":28,"count":29},"前列腺素",2,{"term":31,"count":32},"環氧化酶COX",1,{"term":34,"count":32},"NSAIDs作用機轉",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-112-3-basic-medicine-036","下列藥物中，何者可以拮抗第一型 angiotensin II（AT1）受體，使小動脈及靜脈舒張，達到降血壓的效果？",36,{"webId":41,"stem":42,"number":43,"year":44,"session":29},"nurse-113-2-basic-medicine-032","有關全身性麻醉劑 propofol，下列敘述何者正確？",32,113,{"webId":46,"stem":47,"number":48,"year":49,"session":32},"nurse-114-1-basic-medicine-026","下列何者是何杰金氏淋巴瘤（Hodgkin lymphoma）的腫瘤細胞？",26,114,{"webId":51,"stem":52,"number":53,"year":54,"session":29},"nurse-115-2-basic-medicine-024","關於肺癌的敘述，下列何者最適當？",24,115,{"webId":56,"stem":57,"number":58,"year":59,"session":32},"nurse-107-1-basic-medicine-018","骨骼肌收縮時的鈣離子是從那種鈣通道釋放出來？",18,107,{"webId":61,"stem":62,"number":63,"year":64,"session":32},"nurse-108-1-basic-medicine-052","下列刺激胃腸蠕動的藥物中，何者的作用機轉為拮抗多巴胺 D 2 受體？",52,108,"2026-09-04",1788510744186]