[{"data":1,"prerenderedAt":68},["ShallowReactive",2],{"q-nurse-112-2-basic-medicine-030":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":37,"lastmod":67},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-112-2-基礎醫學-030","nurse-112-2-basic-medicine-030",112,2,30,"下列關於帕金森氏症的敘述何者錯誤？",{"A":15,"B":16,"C":17,"D":18},"臨床上會造成減慢性動作失調（Hypokinetic movement disorder）","黑質區（substantia nigra）產生 dopamin 的神經元（dopaminergic neuron）會減少","殘存的神經元可能發現 Lewy bodies","長期下來會出現含有 amyloid 的 neuritic plaques 及含有過度磷酸化 tau 蛋白的 neurofibrillary tangles","D",null,[],"本題考點在於帕金森氏症的病理特徵，屬反向題。依神經病理，帕金森氏症因黑質區（substantia nigra）多巴胺神經元退化減少（B 正確），造成減慢性動作失調（A 正確），殘存神經元內可見路易氏體（Lewy body，C 正確）。而 D 所述含類澱粉的神經炎斑塊（neuritic plaques）與過度磷酸化 tau 蛋白的神經纖維纏結（neurofibrillary tangles），是阿茲海默症的招牌病理變化而非帕金森氏症，故錯誤敘述為 D，選 D。","神經退化性疾病病理對比記憶：帕金森＝黑質多巴胺↓＋Lewy body（α-synuclein）；阿茲海默＝amyloid 斑塊（Aβ）＋neurofibrillary tangle（tau）。帕金森臨床四主徵：靜止性顫抖、僵硬、動作遲緩、姿勢不穩，治療以補充多巴胺前驅物 levodopa 為主。可連結基底核運動迴路與多巴胺／乙醯膽鹼平衡失調一併複習。",[25,28,30,32,35],{"term":26,"count":27},"帕金森氏症",6,{"term":29,"count":11},"黑質",{"term":31,"count":11},"多巴胺神經元",{"term":33,"count":34},"Lewy body",1,{"term":36,"count":34},"阿茲海默症病理",[38,42,47,52,57,62],{"webId":39,"stem":40,"number":41,"year":10,"session":11},"nurse-112-2-basic-medicine-031","跨膜 G 蛋白偶合受體（G protein-coupled receptor）中的 Gs 蛋白，主要作用在下列何種酵素？",31,{"webId":43,"stem":44,"number":45,"year":46,"session":34},"nurse-113-1-basic-medicine-027","下列何種病毒必須有B型肝炎病毒（hepatitis B virus）存在才能感染人體？",27,113,{"webId":48,"stem":49,"number":50,"year":46,"session":51},"nurse-113-3-basic-medicine-021","有關細胞凋亡（apoptosis）的敘述，下列何者最不適當？",21,3,{"webId":53,"stem":54,"number":55,"year":56,"session":34},"nurse-115-1-basic-medicine-019","下列何者不具有味蕾？",19,115,{"webId":58,"stem":59,"number":60,"year":61,"session":11},"nurse-106-2-basic-medicine-043","有關克隆氏疾病（Crohn disease）的臨床病理特徵，下列敘述何者正確？",43,106,{"webId":63,"stem":64,"number":65,"year":66,"session":11},"nurse-107-2-basic-medicine-077","下列何種肝炎病毒，主要經由飲食傳染？",77,107,"2026-09-04",1788510746388]