[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-2-basic-medicine-043":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-111-2-基礎醫學-043","nurse-111-2-basic-medicine-043",111,2,43,"關於第 I 類 MHC 分子呈現經由內源性路徑產生的抗原，下列敘述何者正確？",{"A":15,"B":16,"C":17,"D":18},"細胞主要從吞噬作用獲得抗原","抗原在溶小體（lysosome）被降解成短胜肽","抗原在蛋白酶體（proteasome）被降解成短胜肽","是個體清除胞外菌相當重要的作用機制","C",null,[],"本題考點為第 I 類 MHC 分子呈現內源性抗原的路徑。第 I 類 MHC 呈現細胞內（內源性，如病毒蛋白）抗原：這些蛋白在細胞質的蛋白酶體（proteasome）被降解成短胜肽，經 TAP 送入內質網與 MHC I 結合，呈現給 CD8+ T 細胞，故選 C。(A)吞噬作用與(B)溶小體降解屬外源性抗原、第 II 類 MHC 路徑。(D)清除胞外菌為第 II 類 MHC 與抗體的功能，非第 I 類，故皆非答案。","兩條路徑對比：內源性→蛋白酶體→MHC I→CD8（毒殺）；外源性→溶小體→MHC II→CD4（輔助）。記憶口訣「一內八、二外四」（MHC I 對內源性與 CD8；MHC II 對外源性與 CD4）。MHC I 幾乎所有有核細胞都表現，供免疫系統監視病毒感染與腫瘤細胞，是細胞毒殺免疫的基礎。",[25,27,30,32],{"term":26,"count":11},"蛋白酶體",{"term":28,"count":29},"第 I 類 MHC",1,{"term":31,"count":29},"內源性抗原路徑",{"term":33,"count":29},"CD8 T 細胞",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-2-basic-medicine-044","補體活化啟動一系列的蛋白質水解產生次單位「a」、「b」與其他次單位，具備不同的生物活性。下列何者是補體 C3b 主要的功能？",44,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-2-basic-medicine-040","下列何種青黴素衍生物，可用於治療綠膿桿菌（Pseudomonas aeruginosa）之感染？",40,112,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-113-1-basic-medicine-034","下列何者不屬於類鴉片藥物戒斷症候群？",34,113,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-2-basic-medicine-032","下列何者不屬於毒蕈鹼拮抗劑（muscarinic antagonist）的臨床適應症？",32,114,{"webId":55,"stem":56,"number":57,"year":58,"session":29},"nurse-106-1-basic-medicine-036","下列何種腫瘤之發生最符合基因雙重打擊理論（two hit hypothesis）？",36,106,{"webId":60,"stem":61,"number":62,"year":63,"session":29},"nurse-107-1-basic-medicine-070","下列何者是李斯特菌（Listeria monocytogenes）主要傳染途徑？",70,107,"2026-09-04",1788510737385]