[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-2-basic-medicine-040":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-111-2-基礎醫學-040","nurse-111-2-basic-medicine-040",111,2,40,"Imatinib 是慢性骨髓性白血病（chronic myeloid leukemia）的標靶療法用藥，下列何者為其作用機轉？",{"A":15,"B":16,"C":17,"D":18},"抑制 BCR-ABL","抑制 EGF receptor","抑制 HER2","抑制 c-KIT","A",null,[],"本題考點為標靶藥 Imatinib 的作用機轉。慢性骨髓性白血病（CML）帶有費城染色體 t(9;22)，產生 BCR-ABL 融合基因，是持續活化的酪胺酸激酶；Imatinib 為酪胺酸激酶抑制劑，專一抑制 BCR-ABL，阻斷異常增生訊號，故選 A。(B)EGFR 為 gefitinib 等肺癌用藥標的。(C)HER2 為 trastuzumab（乳癌）標的。(D)c-KIT 雖亦可被 imatinib 抑制（用於胃腸道基質瘤），但 CML 的定義性標的為 BCR-ABL，故選 A。","BCR-ABL 融合蛋白使 ATP 結合位持續活化下游增生訊號，imatinib 佔據其 ATP 口袋阻斷磷酸化，為第一個成功的分子標靶藥範例。附帶：imatinib 也抑制 c-KIT 與 PDGFR，故用於 GIST；答題時緊扣「CML＝費城染色體＝BCR-ABL」即為主標的，不被 c-KIT 干擾。",[25,27,29,31],{"term":26,"count":11},"Imatinib",{"term":28,"count":11},"BCR-ABL 融合基因",{"term":30,"count":11},"酪胺酸激酶抑制劑",{"term":32,"count":33},"費城染色體",1,[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-2-basic-medicine-041","下列那一種作用過程，不能用來傳遞細菌的遺傳物質？",41,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-2-basic-medicine-037","下列何種藥物是屬於長效型治療氣喘的藥物，但不具有抗發炎作用，無法快速緩解急性氣喘發作？",37,112,{"webId":45,"stem":46,"number":47,"year":48,"session":33},"nurse-113-1-basic-medicine-031","在治療慢性阻塞性肺病（COPD）的藥物中，下列何者可抑制乙醯膽鹼（ACh）受體，以減少黏液之分泌？",31,113,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-2-basic-medicine-029","小腦天幕疝脫（transtentorial herniation），顳葉內側緣被擠壓時，下列何種變化最少見？",29,114,{"webId":55,"stem":56,"number":57,"year":58,"session":33},"nurse-106-1-basic-medicine-033","下列何種細胞在慢性發炎的病灶中出現的機會最少？",33,106,{"webId":60,"stem":61,"number":62,"year":63,"session":33},"nurse-107-1-basic-medicine-067","抗體辨識抗原的專一性由何者決定？",67,107,"2026-09-04",1788510737366]