[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-2-basic-medicine-038":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-111-2-基礎醫學-038","nurse-111-2-basic-medicine-038",111,2,38,"關於甲狀腺機能亢進（hyperthyroidism）治療藥物 Propylthiouracil 之敘述，下列何者錯誤？",{"A":15,"B":16,"C":17,"D":18},"屬於 thionamides 類藥物，會抑制周邊 T4 轉化成 T3","可抑制甲狀腺素合成過程之碘化反應","對於已經儲存在腺體中的甲狀腺素仍有抑制的作用","Methimazole 較 Propylthiouracil 的藥效長，且較有致畸胎之風險","C",null,[],"本題考點為抗甲狀腺藥 Propylthiouracil（PTU）敘述中的錯誤選項。PTU 屬 thionamides，抑制甲狀腺過氧化酶而阻斷碘化與偶聯反應，並可抑制周邊 T4 轉為 T3；但它只能阻止新甲狀腺素合成，對已儲存在腺體膠質中的甲狀腺素無抑制作用，故起效需數週，敘述 C 錯誤，選 C。(A)(B)正確描述其機轉。(D)Methimazole 藥效較長且致畸胎風險較高，敘述正確。","thionamides 起效慢正是因為無法清除既已合成儲存的荷爾蒙，須待庫存耗盡。孕期第一孕期選 PTU（methimazole 有胚胎病風險），中後期可換 methimazole。記憶重點：PTU 額外具「周邊」阻斷 T4→T3 的能力，故甲狀腺風暴時較有利，這也是它與 methimazole 的關鍵差異。",[25,27,30,32],{"term":26,"count":11},"甲狀腺過氧化酶",{"term":28,"count":29},"Propylthiouracil PTU",1,{"term":31,"count":29},"thionamides",{"term":33,"count":29},"周邊 T4 轉 T3",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-2-basic-medicine-039","一名病人因肺炎感染而住院，菌種分離偵測到 Methicillin 抗藥性的金黃色葡萄球菌，下列何者不適於治療此病人？",39,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-2-basic-medicine-035","下列抗組織胺藥物中，何者可用於改善蕁麻疹（Urticaria）症狀，亦常用於預防暈車暈船？",35,112,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-113-1-basic-medicine-029","進行性多灶性白質腦病（progressive multifocal leukoencephalopathy, PML）是一種髓鞘脫失（demyelination）的病變，臨床上常與免疫抑制有關。此病主要由何種病毒引起？",29,113,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-2-basic-medicine-027","關於 IgA 腎病變（IgA nephropathy）的敘述，下列何者最不適當？",27,114,{"webId":55,"stem":56,"number":57,"year":58,"session":29},"nurse-106-1-basic-medicine-031","胃腺之何種細胞負責分泌胃泌素（gastrin）？",31,106,{"webId":60,"stem":61,"number":62,"year":63,"session":29},"nurse-107-1-basic-medicine-065","在醫院群聚型院內細菌感染傳播中，下列那一種疏失是最常見的原因？",65,107,"2026-09-04",1788510737340]