[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-2-basic-medicine-034":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-111-2-基礎醫學-034","nurse-111-2-basic-medicine-034",111,2,34,"下列何者為 Ethosuximide 治療失神性癲癇（absence seizures）的主要作用機轉？",{"A":15,"B":16,"C":17,"D":18},"抑制 L 型鈣離子通道","抑制 P 型鈣離子通道","抑制 T 型鈣離子通道","抑制 N 型鈣離子通道","C",null,[],"本題考點為抗癲癇藥 Ethosuximide 的作用機轉。失神性癲癇的病理在於視丘神經元 T 型鈣離子通道異常放電，產生 3 Hz 棘慢波；Ethosuximide 選擇性抑制 T 型鈣離子通道，減少視丘節律性放電，故選 C。(A)L 型鈣通道與心肌、血管平滑肌收縮相關，是鈣離子阻斷劑的作用位置，非本藥標的。(B)P 型與(D)N 型鈣通道主要調控神經末梢傳導物質釋放，與失神性癲癇的棘慢波機轉無直接關聯，故皆非答案。","T 型（transient）鈣通道為低電位活化、快速去活化，集中於視丘中繼神經元，是失神性癲癇棘慢波節律的關鍵樞紐。記憶連結：Ethosuximide→T-type→absence 三者綁在一起。相對地 valproic acid 為廣效藥亦可治失神發作，但單純失神性癲癇以 Ethosuximide 為首選；辨題時抓住「T 型鈣通道＝失神」即可快速定位。",[25,28,30,32],{"term":26,"count":27},"Ethosuximide",1,{"term":29,"count":27},"T 型鈣離子通道",{"term":31,"count":27},"失神性癲癇",{"term":33,"count":27},"視丘棘慢波",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-2-basic-medicine-035","下列何者為 Lorsatan 降血壓的作用機制？",35,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-2-basic-medicine-031","跨膜 G 蛋白偶合受體（G protein-coupled receptor）中的 Gs 蛋白，主要作用在下列何種酵素？",31,112,{"webId":45,"stem":46,"number":47,"year":48,"session":27},"nurse-113-1-basic-medicine-025","社區性肺炎（community-acquired pneumonia）指的是患者在日常生活環境中所得到的感染，而非在醫院中的感染。引起典型社區性肺炎最常見的致病菌為何？",25,113,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-2-basic-medicine-023","下列何種自體抗體（autoantibody）與全身性紅斑性狼瘡（systemic lupus erythematosus）最相關？",23,114,{"webId":55,"stem":56,"number":57,"year":58,"session":27},"nurse-106-1-basic-medicine-027","下列有關血壓的敘述，何者錯誤？",27,106,{"webId":60,"stem":61,"number":62,"year":63,"session":27},"nurse-107-1-basic-medicine-061","下列止瀉劑中，何者可增加腸道分節性收縮，屬於類鴉片之藥物？",61,107,"2026-09-04",1788510737302]