[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-2-basic-medicine-030":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-111-2-基礎醫學-030","nurse-111-2-basic-medicine-030",111,2,30,"Creutzfeldt-Jakob 病會造成大腦皮質及深部灰質的海綿狀變形（spongiform transformation），這種病的病因主要與下列何者有關？",{"A":15,"B":16,"C":17,"D":18},"病毒感染","細菌感染","原蟲感染","Prion 蛋白變異","D",null,[],"本題考點為庫賈氏病（Creutzfeldt-Jakob disease）的病因。依神經病理，此病造成大腦皮質與深部灰質海綿狀變性，病因為普利昂蛋白（prion）異常摺疊變異，屬蛋白質構型錯誤誘導鄰近正常蛋白同樣錯誤堆積的傳染性病變，故選 D。A 病毒、B 細菌、C 原蟲感染皆非本病病因，普利昂不含核酸、無法以一般病原機制解釋，故選 D。","普利昂疾病（傳染性海綿狀腦病）的核心是正常 PrPᶜ 被誘導轉為異常 PrPˢᶜ 構型，抗蛋白酶分解、逐漸堆積致神經元空泡化與海綿狀變性。臨床表現為快速進展性失智、肌陣攣與運動失調，預後極差。此類病原無核酸、耐高溫與一般消毒，是「蛋白質即感染因子」的顛覆性概念。同類含庫魯症與致死性家族失眠症。",[25,27,30,32],{"term":26,"count":11},"庫賈氏病",{"term":28,"count":29},"普利昂蛋白(prion)",1,{"term":31,"count":29},"海綿狀變性",{"term":33,"count":29},"蛋白質構型錯誤",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-2-basic-medicine-031","Amantadine 具有抗巴金森氏症的作用，有關其副作用，下列敘述何者錯誤？",31,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-2-basic-medicine-027","李先生因持續便血而至醫院看診，醫師為他做了大腸鏡切片發現是乙狀結腸癌（Sigmoid Colon Cancer），且肝臟有一可疑病灶。手術切除大腸與部分肝臟之後的病理診斷為分化差的腺癌（poorly-differentiated adenocarcinoma），分期為 T3N1M0。從這個診斷中可以得知下列那項資訊？",27,112,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-113-1-basic-medicine-021","有關組織傷口癒合的敘述，下列何者最不適當？",21,113,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-2-basic-medicine-019","失語症（aphasia）與下列那個腦區受損最為相關？",19,114,{"webId":55,"stem":56,"number":57,"year":58,"session":29},"nurse-106-1-basic-medicine-023","下列何者抑制泌乳素分泌？",23,106,{"webId":60,"stem":61,"number":62,"year":63,"session":29},"nurse-107-1-basic-medicine-057","下列何者屬於 Class III 抗心律不整藥物兼具有 β-blocker 作用？",57,107,"2026-09-04",1788510737254]