[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-2-basic-medicine-027":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-111-2-基礎醫學-027","nurse-111-2-basic-medicine-027",111,2,27,"B 細胞濾泡性淋巴瘤（follicular lymphoma）常見下列何種染色體異常？",{"A":15,"B":16,"C":17,"D":18},"染色體 12 三染色體症（trisomy 12）","t（14, 18）（染色體 14 及 18 轉位）","t（11, 14）（染色體 11 及 14 轉位）","t（9, 22）（染色體 9 及 22 轉位）","B",null,[],"本題考點為濾泡性淋巴瘤（follicular lymphoma）的特徵性染色體異常。依血液病理，濾泡性淋巴瘤最常見 t(14;18) 轉位，使第 18 號染色體的 BCL-2 基因移至第 14 號的免疫球蛋白重鏈啟動子下，造成 BCL-2 過度表現、抑制細胞凋亡，故選 B。A trisomy 12 多見於慢性淋巴球性白血病；C t(11;14) 見於被套細胞淋巴瘤（cyclin D1）；D t(9;22) 為費城染色體，見於慢性骨髓性白血病，皆非濾泡性淋巴瘤特徵，故選 B。","t(14;18) 使 BCL-2 這個抗凋亡蛋白持續高表現，讓濾泡中心 B 細胞逃避程序性死亡而堆積成瘤，是「抗凋亡」致癌的經典範例。常考轉位對照：CML→t(9;22) BCR-ABL；Burkitt→t(8;14) c-MYC；被套細胞→t(11;14) cyclin D1；濾泡性→t(14;18) BCL-2；APL→t(15;17)。記憶時把「基因—疾病」成對背誦最有效率。",[25,27,30,32],{"term":26,"count":11},"濾泡性淋巴瘤",{"term":28,"count":29},"t(14;18) 轉位",1,{"term":31,"count":29},"BCL-2 抗凋亡",{"term":33,"count":29},"染色體轉位對照",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-2-basic-medicine-028","關於 A 型肝炎（hepatitis A）的敘述，下列何者正確？",28,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-2-basic-medicine-024","慢性肉芽腫發炎反應所導致的限制性心包炎，最常見的病原菌或病因是：",24,112,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-113-1-basic-medicine-018","下列何者調控並可加速肝臟分泌膽汁？",18,113,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-2-basic-medicine-016","下列何者可將睪固酮轉換為動情二醇（17β-estradiol）？",16,114,{"webId":55,"stem":56,"number":57,"year":58,"session":29},"nurse-106-1-basic-medicine-020","下列自主神經傳導物質接受器之作用，何者會引起皮膚及腹腔內臟的血管收縮？",20,106,{"webId":60,"stem":61,"number":62,"year":63,"session":29},"nurse-107-1-basic-medicine-054","在耳鼻喉科與家醫科門診，針對過敏性鼻炎與氣喘患者，處方以 Zileuton 治療，此藥物主要抑制下列何種酵素？",54,107,"2026-09-04",1788510737219]