[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-1-basic-medicine-052":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-111-1-基礎醫學-052","nurse-111-1-basic-medicine-052",111,1,52,"下列藥物中，何者不適用於治療生長激素分泌過多而產生的肢端肥大症？",{"A":15,"B":16,"C":17,"D":18},"Octreotide","Bromocriptine","Corticotropin","Pegvisomant","C",null,[],"本題考點為肢端肥大症（生長激素過多）的藥物治療，須選不適用者。Corticotropin（ACTH）是刺激腎上腺皮質分泌皮質醇的促腎上腺皮質激素，與抑制生長激素無關，反而屬刺激性荷爾蒙，故不適用，選 C。A 的 Octreotide 是體抑素（somatostatin）類似物，可抑制 GH 分泌，為第一線用藥。B 的 Bromocriptine 是多巴胺致效劑，可抑制部分 GH 分泌腺瘤的分泌。D 的 Pegvisomant 是生長激素受體拮抗劑，阻斷 GH 在周邊作用、降低 IGF-1。三者皆為治療肢端肥大症的正確方向，唯 C 反向。","治療策略：肢端肥大症多因腦下垂體 GH 分泌腺瘤，首選手術切除；藥物包括 somatostatin 類似物（octreotide、lanreotide，直接抑制 GH）、GH 受體拮抗劑（pegvisomant，阻斷周邊訊息使 IGF-1 下降）、多巴胺致效劑（bromocriptine、cabergoline，對部分腫瘤有效）。ACTH（corticotropin）作用於腎上腺產皮質醇，屬 HPA 軸，與 GH 軸無關，甚至方向相反。記憶：治 GH 過多＝『抑 GH（octreotide）或擋 GH 受體（pegvisomant）』。",[25,28,30,32],{"term":26,"count":27},"肢端肥大症",3,{"term":29,"count":11},"Octreotide(體抑素類似物)",{"term":31,"count":11},"Pegvisomant(GH 受體拮抗劑)",{"term":33,"count":11},"Corticotropin(ACTH)",[35,39,44,48,53,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-1-basic-medicine-053","下列抗生素中，何者不會作用在細菌的核糖體上？",53,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-1-basic-medicine-019","下列有關心衰竭病程中的代償調節作用之敘述，何者正確？",19,112,{"webId":45,"stem":46,"number":47,"year":43,"session":27},"nurse-112-3-basic-medicine-013","下列腦區何者未參與調節意識（consciousness）的清醒或睡眠狀態？",13,{"webId":49,"stem":50,"number":51,"year":52,"session":11},"nurse-114-1-basic-medicine-011","下列那兩個體內空腔之間沒有實質構造區隔，其中一個空腔內如果產生積水，會在兩個空腔內互相流通？",11,114,{"webId":54,"stem":55,"number":56,"year":57,"session":58},"nurse-115-2-basic-medicine-015","當血糖濃度高於正常範圍時，一般會產生下列何種調節反應？",15,115,2,{"webId":60,"stem":61,"number":62,"year":63,"session":58},"nurse-106-2-basic-medicine-079","有關抗病毒藥物的敘述，何者正確？",79,106,"2026-09-04",1788510733140]