[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-111-1-basic-medicine-049":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-111-1-基礎醫學-049","nurse-111-1-basic-medicine-049",111,1,49,"Dobutamine 可用於增加急性鬱血性心臟衰竭（congestive heart failure）病人的心輸出量（cardiac output），其作用主要是透過活化下列何種受體而產生？",{"A":15,"B":16,"C":17,"D":18},"β 1 腎上腺素受體（β 1 adrenergic receptor）","β 2 腎上腺素受體（β 2 adrenergic receptor）","D 1 多巴胺受體（D 1 dopaminergic receptor）","D 2 多巴胺受體（D 2 dopaminergic receptor）","A",null,[],"本題考點為 Dobutamine 增加心輸出量的受體作用機轉。Dobutamine 是合成的擬交感神經藥，主要選擇性活化心臟的 β1 腎上腺素受體，透過提高心肌收縮力（正性肌力）與心跳而增加心輸出量，用於急性鬱血性心衰竭，故選 A。β2 受體（B）主要分布於支氣管與血管平滑肌，作用是舒張，並非其主要增加心收縮的途徑。D1 多巴胺受體（C）由 dopamine 在低劑量活化以擴張腎與腸繫膜血管，非 dobutamine 主作用。D2 多巴胺受體（D）與突觸前抑制、催吐化學受器區有關，也非本藥主軸。故 β1 受體為正解。","藥理對比：Dobutamine 以 β1>β2 選擇性提升心收縮力，對後負荷影響小、較不明顯升壓，適合心因性低輸出的短期支持。Dopamine 則呈劑量依賴：低劑量（D1）擴腎血管、中劑量（β1）增心收縮、高劑量（α1）血管收縮升壓。β1 受體透過 Gs → 腺苷酸環化酶 → cAMP 上升 → 蛋白激酶 A 增加鈣內流，強化心肌收縮。記憶：『Dobutamine 打的是心臟的 β1』。",[25,28,30,32],{"term":26,"count":27},"Dobutamine",2,{"term":29,"count":11},"β1 腎上腺素受體",{"term":31,"count":11},"正性肌力作用",{"term":33,"count":11},"cAMP 訊息路徑",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-1-basic-medicine-050","使用下列何種吸入性麻醉劑，最易引起心律不整（cardiac arrhythmia）之副作用？",50,{"webId":40,"stem":41,"number":42,"year":43,"session":11},"nurse-112-1-basic-medicine-016","下列何種反應是阻斷毒蕈鹼類受器（muscarinic receptors）所造成？",16,112,{"webId":45,"stem":46,"number":47,"year":43,"session":48},"nurse-112-3-basic-medicine-010","支配橫膈（diaphragm）的神經主要源自：",10,3,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-114-1-basic-medicine-008","正常情況下，下列何種物質在腎臟再吸收（reabsorption）的比例最高？",8,114,{"webId":55,"stem":56,"number":57,"year":58,"session":27},"nurse-115-2-basic-medicine-012","肌肉收縮的滑動絲（sliding filament）模型描述的是那兩種蛋白間的交互作用？",12,115,{"webId":60,"stem":61,"number":62,"year":63,"session":27},"nurse-106-2-basic-medicine-076","臺灣每年夏天常有登革熱的區域流行，對於登革熱病毒（dengue virus）的特性，下列敘述何者錯誤？",76,106,"2026-09-04",1788510733111]