[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-111-1-basic-medicine-023":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-111-1-基礎醫學-023","nurse-111-1-basic-medicine-023",111,1,23,"下列由內皮細胞分泌的因子中，何者不會使血管舒張？",{"A":15,"B":16,"C":17,"D":18},"一氧化氮（NO）","緩激肽（bradykinin）","前列腺環素（prostacyclin）","內皮因子-1（endothelin-1）","D",null,[],"本題考點在於血管內皮細胞分泌的血管活性因子,要找出「不使血管舒張」者。內皮素-1(endothelin-1)是已知最強效的血管收縮物質之一,作用於 ETA 受體使平滑肌收縮、血管管徑變窄,故它「不會使血管舒張」,選 D。A 一氧化氮(NO)是內皮衍生舒張因子(EDRF),經 cGMP 使平滑肌鬆弛而舒張血管。B 緩激肽會刺激內皮釋放 NO 與前列環素,間接造成血管舒張。C 前列環素(prostacyclin, PGI₂)經 cAMP 使血管平滑肌鬆弛並抑制血小板凝集,亦為舒張因子。唯內皮素-1 屬收縮性,故正解為 D。","內皮功能對照表——舒血管:NO、前列環素(PGI₂)、緩激肽、內皮衍生超極化因子(EDHF);縮血管:內皮素-1(ET-1)、血管收縮素 II(內皮上 ACE 生成)、thromboxane A₂。NO 由 eNOS 催化 L-精胺酸產生,活化鳥苷酸環化酶提升 cGMP;PGI₂ 則走 cAMP 路徑,兩者並抑制血小板聚集,維持血管抗栓。內皮功能失調(NO 下降、ET-1 上升)是高血壓與動脈粥狀硬化的早期病理機轉,臨床意義重大,屬延伸考點。",[25,28,30,32],{"term":26,"count":27},"血管收縮",6,{"term":29,"count":11},"內皮素-1 endothelin-1",{"term":31,"count":11},"一氧化氮 NO",{"term":33,"count":11},"前列腺環素 PGI2",[35,39,44,49,55,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-111-1-basic-medicine-024","下列有關微血管及組織液交換的敘述，何者錯誤？",24,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-111-2-basic-medicine-040","Imatinib 是慢性骨髓性白血病（chronic myeloid leukemia）的標靶療法用藥，下列何者為其作用機轉？",40,2,{"webId":45,"stem":46,"number":47,"year":48,"session":43},"nurse-112-2-basic-medicine-034","Bupropion 除可當抗憂鬱藥物外，尚具有何項藥理功能？",34,112,{"webId":50,"stem":51,"number":52,"year":53,"session":54},"nurse-113-3-basic-medicine-032","下列安眠藥中，何者能活化 melatonin receptor（褪黑激素受體）？",32,113,3,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-115-1-basic-medicine-036","有關吸入性麻醉劑的最低肺泡濃度（minimum alveolar concentration, MAC）之敘述，下列何者最不適當？",36,115,{"webId":61,"stem":62,"number":63,"year":64,"session":43},"nurse-106-2-basic-medicine-050","下列有關腎上腺素（epinephrine）的敘述，何者正確？",50,106,"2026-09-04",1788510732867]