[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-110-2-basic-medicine-069":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-110-2-基礎醫學-069","nurse-110-2-basic-medicine-069",110,2,69,"主要抑制麥角固醇（ergosterol）合成有關之抗真菌藥物為何？",{"A":15,"B":16,"C":17,"D":18},"Polyenes 及 Azoles","Echinocandins","Azoles 及 Fluorocytosine","Polyenes 及 Echinocandins","A",null,[],"本題考點為抗真菌藥與麥角固醇（ergosterol）合成的關係。考點在於辨識與 ergosterol 直接相關的兩類藥為 Polyenes 與 Azoles，故選 A。Azoles 抑制 lanosterol 轉為 ergosterol 的 14-α-demethylase，阻斷其合成；Polyenes（如 amphotericin B）則結合已生成的 ergosterol、在膜上形成孔洞。B Echinocandins 抑制的是細胞壁的 β-glucan 合成，與 ergosterol 無關；C、D 皆混入 Fluorocytosine（抑核酸合成）或 Echinocandins，故非最完整正確的組合。","須把抗真菌藥依「攻擊標的」分層記憶：作用於細胞膜 ergosterol 者為 Azoles（抑制合成）與 Polyenes（結合破壞）；作用於細胞壁 β-glucan 者為 Echinocandins（-fungin 類）；抑制核酸合成者為 Flucytosine；抑制有絲分裂者為 Griseofulvin。本題問「與 ergosterol 合成有關」，嚴格說 Azoles 抑制合成、Polyenes 結合成品，官方將兩者並列為與 ergosterol 相關者。記憶法：Azole＝擋合成、Polyene＝黏成品、Echinocandin＝拆牆。可連結概念：選擇毒性來自真菌用 ergosterol、人用 cholesterol。",[25,28,30,32,34],{"term":26,"count":27},"麥角固醇 ergosterol",1,{"term":29,"count":27},"Azoles 抑制 14-α-demethylase",{"term":31,"count":27},"Polyenes 結合 ergosterol",{"term":33,"count":27},"Echinocandins 抑制 β-glucan",{"term":35,"count":27},"抗真菌藥標的分類",[37,41,46,51,56,60],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-110-2-basic-medicine-070","下列何種細胞源於卵黃囊，發育後長期駐守在組織中，負責組織維護與修復的功能？",70,{"webId":42,"stem":43,"number":44,"year":45,"session":11},"nurse-111-2-basic-medicine-006","手術時不小心移除下列何者，最可能直接造成血鈣濃度下降？",6,111,{"webId":47,"stem":48,"number":49,"year":50,"session":27},"nurse-112-1-basic-medicine-050","若 A 血型的人輸血給 B 血型的人，受血者因抗原刺激產生的抗體是屬於：",50,112,{"webId":52,"stem":53,"number":54,"year":55,"session":11},"nurse-113-2-basic-medicine-048","有關猴痘，下列敘述何者最適當？",48,113,{"webId":57,"stem":58,"number":11,"year":59,"session":27},"nurse-115-1-basic-medicine-002","手舉起椅子一動也不動地罰站，此時維持靜止且正在施力的上臂肌肉之收縮型態為下列何者？",115,{"webId":61,"stem":62,"number":63,"year":64,"session":11},"nurse-106-2-basic-medicine-016","下列何者屬於邊緣系統？",16,106,"2026-09-04",1788510727910]