[{"data":1,"prerenderedAt":67},["ShallowReactive",2],{"q-nurse-110-2-basic-medicine-061":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":66},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-110-2-基礎醫學-061","nurse-110-2-basic-medicine-061",110,2,61,"下列何種藥物可預防或減輕因使用 Aspirin 造成之消化性潰瘍？",{"A":15,"B":16,"C":17,"D":18},"Biscodyl","Lactulose","Misoprostol","Sorbitol","C",null,[],"本題考點為預防非類固醇抗發炎藥（Aspirin）造成消化性潰瘍的用藥。考點在於辨識 Misoprostol 為 prostaglandin E1 類似物，可補充被 Aspirin 抑制的前列腺素，恢復胃黏膜的保護（促黏液與碳酸氫鹽分泌、抑制胃酸），故選 C。A Bisacodyl、D Sorbitol 皆為刺激或滲透性瀉劑，B Lactulose 為滲透性瀉劑兼降血氨用途，三者作用在腸道排便，與胃黏膜保護無關，無法預防 NSAID 潰瘍。","Aspirin 等 NSAID 抑制 COX-1，使保護性前列腺素減少，胃黏液與黏膜血流下降而易生潰瘍；Misoprostol 直接補回 PGE1 效應，是唯一針對此機轉設計的預防藥。副作用為腹瀉與子宮收縮，故孕婦禁用（會誘發流產）。臨床上 PPI 也常用於 NSAID 潰瘍預防且耐受性較佳。記憶法：Aspirin 打掉前列腺素，Misoprostol 補回前列腺素。可連結概念：COX-1／COX-2、前列腺素的胃保護作用、選擇性 COX-2 抑制劑的腸胃取捨。",[25,27,29,31,33],{"term":26,"count":11},"胃黏膜保護",{"term":17,"count":28},1,{"term":30,"count":28},"prostaglandin E1 類似物",{"term":32,"count":28},"NSAID 潰瘍",{"term":34,"count":28},"COX-1 抑制",[36,40,45,50,55,61],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-110-2-basic-medicine-062","有關體重控制藥物 Lorcaserin 的敘述，下列何者錯誤？",62,{"webId":41,"stem":42,"number":43,"year":44,"session":28},"nurse-111-1-basic-medicine-078","下列何種病毒會造成潛伏感染（latent infection），病毒會潛伏在神經節的神經細胞中？",78,111,{"webId":46,"stem":47,"number":48,"year":49,"session":28},"nurse-112-1-basic-medicine-042","補體活化路徑中所產生的膜攻擊複合體（membrane attack complex）包含了下列何者？",42,112,{"webId":51,"stem":52,"number":53,"year":54,"session":11},"nurse-113-2-basic-medicine-040","有關克隆氏症（Crohn’s disease）之治療，下列那一個藥物屬於 TNF-α 抑制劑？",40,113,{"webId":56,"stem":57,"number":58,"year":59,"session":60},"nurse-114-3-basic-medicine-044","有關過敏反應，下列何者不是由抗體引起？",44,114,3,{"webId":62,"stem":63,"number":64,"year":65,"session":11},"nurse-106-2-basic-medicine-008","下列有關男性生殖器官的敘述，何者錯誤？",8,106,"2026-09-04",1788510727835]