[{"data":1,"prerenderedAt":69},["ShallowReactive",2],{"q-nurse-110-2-basic-medicine-059":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":37,"lastmod":68},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-110-2-基礎醫學-059","nurse-110-2-basic-medicine-059",110,2,59,"抗高血壓藥物 Aliskiren 的藥理作用為何？",{"A":15,"B":16,"C":17,"D":18},"直接抑制血管內皮受體","直接抑制腎素活性","抑制心房利鈉胜肽代謝","抑制血管緊縮素受體","B",null,[],"本題考點為抗高血壓新藥 Aliskiren 的作用位置。考點在於辨識它是直接腎素抑制劑（direct renin inhibitor），結合並抑制腎素活性，阻斷腎素將 angiotensinogen 轉為 angiotensin I 的第一步，從源頭壓低整條 RAAS 系統，故選 B。A 直接抑制血管內皮受體並非其機轉；C 抑制心房利鈉胜肽代謝是 neprilysin 抑制劑（如 sacubitril）的作用；D 抑制血管緊縮素受體則是 ARB（-sartan 類）所為，皆非 Aliskiren 的作用點。","RAAS 級聯可在多點阻斷：腎素這一步（Aliskiren）、ACE 轉換這一步（ACEI，-pril）、AT1 受體這一步（ARB，-sartan）。Aliskiren 因作用最上游，理論上抑制最完整，但臨床上與 ACEI\u002FARB 併用會增加高血鉀與腎損傷風險，糖尿病病人尤需避免合併。記憶法：Aliskiren＝「A 開頭卡最前面」＝直接卡腎素。可連結概念：angiotensinogen→AngI→AngII 級聯、醛固酮、代償性腎素上升與各類 RAAS 藥的作用點對照。",[25,28,30,33,35],{"term":26,"count":27},"RAAS 系統",5,{"term":29,"count":11},"Aliskiren",{"term":31,"count":32},"直接腎素抑制劑",1,{"term":34,"count":32},"angiotensinogen",{"term":36,"count":32},"ACEI 與 ARB 作用點",[38,42,47,52,57,63],{"webId":39,"stem":40,"number":41,"year":10,"session":11},"nurse-110-2-basic-medicine-060","有關具黏膜保護作用的 Sucralfate 敘述，下列何者錯誤？",60,{"webId":43,"stem":44,"number":45,"year":46,"session":32},"nurse-111-1-basic-medicine-076","下列關於黴漿菌（Mycoplasma）的敘述，何者錯誤？",76,111,{"webId":48,"stem":49,"number":50,"year":51,"session":32},"nurse-112-1-basic-medicine-040","下列何種成癮性物質是透過血清素受體來產生幻覺？",40,112,{"webId":53,"stem":54,"number":55,"year":56,"session":11},"nurse-113-2-basic-medicine-038","長期口服 prednisone 之病人最常出現下列何種副作用？",38,113,{"webId":58,"stem":59,"number":60,"year":61,"session":62},"nurse-114-3-basic-medicine-042","下列何種抗體常以雙聚體方式分泌？",42,114,3,{"webId":64,"stem":65,"number":66,"year":67,"session":11},"nurse-106-2-basic-medicine-006","正常情形下，白血球中數量最多與直徑最大的分別是：",6,106,"2026-09-04",1788510727823]