[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-110-2-basic-medicine-052":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-110-2-基礎醫學-052","nurse-110-2-basic-medicine-052",110,2,52,"動情素在臨床上用來治療攝護腺癌，是因為下列何種藥理作用？",{"A":15,"B":16,"C":17,"D":18},"可以增加腎素（renin）的分泌","可以和攝護腺癌細胞的動情素受體結合，而調控基因表現","具有拮抗雄性素的作用","可以經由腎臟代謝產生代謝物，而抑制攝護腺癌生長","C",null,[],"本題考點在動情素(estrogen)治療攝護腺癌的藥理機轉。攝護腺癌屬雄性素依賴性腫瘤,其生長受睪固酮驅動。動情素經負回饋抑制下視丘-腦下垂體軸,減少促性腺激素(LH)釋放、進而降低睪丸睪固酮生成,達到功能性去勢、拮抗雄性素的效果以抑制腫瘤,故選C。A增加腎素分泌與抗癌無關;B與腫瘤細胞動情素受體結合調控基因並非其主要抗癌機轉;D經腎代謝產生代謝物抑癌亦非其作用途徑。故機轉為拮抗雄性素作用。","攝護腺癌為雄性素依賴,治療核心是雄性素剝奪(ADT):estrogen(如diethylstilbestrol)以負回饋降LH→降睪固酮,但有心血管血栓副作用故漸少用;現多用GnRH致效劑(leuprolide,持續刺激反致下調)或拮抗劑、抗雄性素(flutamide、bicalutamide阻受體)、CYP17抑制劑(abiraterone)。可連結PSA追蹤、骨轉移疼痛管理與去勢阻抗性攝護腺癌的治療。",[25,28,31,33],{"term":26,"count":27},"攝護腺癌",3,{"term":29,"count":30},"動情素",1,{"term":32,"count":30},"雄性素剝奪",{"term":34,"count":30},"負回饋抑制",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-110-2-basic-medicine-053","免疫抑制劑 mycophenolate mofetil 用於腎臟移植時，可減少淋巴細胞異常增殖而緩解腎臟排斥作用，其作用機轉為何？",53,{"webId":41,"stem":42,"number":43,"year":44,"session":30},"nurse-111-1-basic-medicine-069","絕對厭氧菌不能在有氧環境下生長，是因為缺乏以下何種酵素？",69,111,{"webId":46,"stem":47,"number":48,"year":49,"session":30},"nurse-112-1-basic-medicine-033","成年人長期咳嗽，經確診為黴漿菌感染，其處方藥物為口服 clarithromycin，有關此抗生素之敘述，下列何者正確？",33,112,{"webId":51,"stem":52,"number":53,"year":54,"session":11},"nurse-113-2-basic-medicine-031","有關麥角生物鹼（ergot alkaloids）的作用，下列敘述何者錯誤？",31,113,{"webId":56,"stem":57,"number":58,"year":59,"session":27},"nurse-114-3-basic-medicine-035","關於秋水仙素（colchicine），下列敘述何者錯誤？",35,114,{"webId":61,"stem":62,"number":63,"year":64,"session":30},"nurse-106-1-basic-medicine-079","立克次體與病毒相似的特性為何？",79,106,"2026-09-04",1788510727766]