[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-110-2-basic-medicine-025":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-110-2-基礎醫學-025","nurse-110-2-basic-medicine-025",110,2,25,"甲狀腺激素（thyroid hormone）合成的第一個步驟，下列過程何者正確？",{"A":15,"B":16,"C":17,"D":18},"酪胺酸（tyrosine）的碘化","甲狀腺素（T 4 ）轉變為三碘甲狀腺素（T 3 ）","雙碘酪胺酸（DIT）與單碘酪胺酸（MIT）結合","碘離子（I - ）轉換為碘分子（I 2 ）","D",null,[],"本題考點在甲狀腺激素合成的先後順序。依甲狀腺過氧化酶(TPO)催化的流程,碘離子先被捕捉入濾泡細胞,接著在濾泡腔面被氧化,即碘離子(I⁻)轉換為活性碘,此氧化為後續反應的起始關鍵,故選D。A酪胺酸的碘化(有機化)須在碘被氧化後才發生,屬較後步驟;C的DIT與MIT結合(偶合)產生T4、T3,更在碘化之後;B的T4轉T3屬周邊組織去碘作用,已非合成而是活化階段。故最先發生者為碘的氧化。","口訣『捕—氧—化—合』:iodide trapping(Na\u002FI symporter)→oxidation(TPO)→organification(酪胺酸碘化成MIT、DIT)→coupling(MIT+DIT=T3、DIT+DIT=T4)。抗甲狀腺藥PTU、methimazole即抑制TPO,阻斷氧化與偶合;PTU另抑制周邊T4→T3。可連結甲狀腺腫、Wolff-Chaikoff效應與放射碘治療。",[25,27,30,32],{"term":26,"count":11},"甲狀腺過氧化酶",{"term":28,"count":29},"碘的氧化",1,{"term":31,"count":29},"有機化",{"term":33,"count":29},"甲狀腺激素合成",[35,39,44,49,54,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-110-2-basic-medicine-026","有關排卵過程的敘述，下列何者正確？",26,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-111-1-basic-medicine-042","肝臟因為慢性右側心臟衰竭發生嚴重充血現象時，肝小葉中心區域出現出血性壞死，稱為：",42,111,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-112-1-basic-medicine-006","將導管從頸內靜脈放置到上腔靜脈，過程中導管須穿過那條血管？",6,112,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-113-2-basic-medicine-004","下列何者為隔開心臟的右心房與右心室之間的瓣膜？",4,113,{"webId":55,"stem":56,"number":57,"year":58,"session":59},"nurse-114-3-basic-medicine-008","想要聽清楚主動脈半月瓣（aortic semilunar valve）關閉的心音，要將聽診器置放於何處最佳？",8,114,3,{"webId":61,"stem":62,"number":63,"year":64,"session":29},"nurse-106-1-basic-medicine-052","局部麻醉劑使用在發炎組織時其藥效降低，最主要的原因為何？",52,106,"2026-09-04",1788510727530]