[{"data":1,"prerenderedAt":68},["ShallowReactive",2],{"q-nurse-110-1-basic-medicine-066":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":38,"lastmod":67},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-110-1-基礎醫學-066","nurse-110-1-basic-medicine-066",110,1,66,"惡性貧血的病因是因為體內產生對抗下列何者的自體抗體？",{"A":15,"B":16,"C":17,"D":18},"維生素 C","維生素 B 12 內在因子（intrinsic factor）","胰島素（insulin）","血清素（serotonin）","B",null,[],"本題考點是惡性貧血的自體免疫機轉。依病生理，惡性貧血是自體抗體破壞胃壁細胞並對抗內在因子(intrinsic factor)，使維生素B12無法在迴腸末端吸收，導致巨球性貧血，故選B。維生素C缺乏與壞血病相關，非此免疫機轉；胰島素自體抗體屬糖尿病範疇；血清素為神經傳導物質，與B12吸收無關。三者皆非惡性貧血的抗體標的，故答案為B。","機轉延伸：內在因子由胃壁細胞分泌，須與B12結合才能在迴腸受體吸收；抗內在因子抗體或抗壁細胞抗體阻斷此環節，造成B12缺乏。B12缺乏除巨球性(大球性)貧血外，還會傷及脊髓後索與側索造成神經症狀。記憶：Pernicious=Parietal cell+intrinsic factor，Schilling test為經典診斷法。",[25,28,31,34,36],{"term":26,"count":27},"內在因子",6,{"term":29,"count":30},"惡性貧血",4,{"term":32,"count":33},"巨球性貧血",2,{"term":35,"count":11},"維生素B12",{"term":37,"count":11},"胃壁細胞",[39,43,48,52,57,62],{"webId":40,"stem":41,"number":42,"year":10,"session":11},"nurse-110-1-basic-medicine-067","藍氏（Lancefield）血清學分類法，主要是依溶血性鏈球菌之何種構造的抗原不同加以分類？",67,{"webId":44,"stem":45,"number":46,"year":47,"session":11},"nurse-111-1-basic-medicine-003","內側蹄系（medial lemniscus）與下列何訊息傳遞有關？",3,111,{"webId":49,"stem":50,"number":51,"year":47,"session":33},"nurse-111-2-basic-medicine-017","有關突觸後電位（postsynaptic potentials）的敘述，下列何者正確？",17,{"webId":53,"stem":54,"number":55,"year":56,"session":11},"nurse-113-1-basic-medicine-015","下列何者是負責供應肝臟充氧血的血管？",15,113,{"webId":58,"stem":59,"number":60,"year":61,"session":33},"nurse-114-2-basic-medicine-019","失語症（aphasia）與下列那個腦區受損最為相關？",19,114,{"webId":63,"stem":64,"number":65,"year":66,"session":11},"nurse-106-1-basic-medicine-013","庫佛氏細胞（Kupffer's cell）位於肝小葉的何處？",13,106,"2026-09-04",1788510719721]