[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-109-2-basic-medicine-060":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-109-2-基礎醫學-060","nurse-109-2-basic-medicine-060",109,2,60,"Cimetidine抑制胃酸分泌的藥理作用，為下列何種機轉？",{"A":15,"B":16,"C":17,"D":18},"活化prostaglandin receptor","拮抗H 2 histamine receptor","拮抗cholinergic receptor","抑制proton pump","B",null,[],"本題考點在於Cimetidine抑制胃酸分泌的受體機轉。考點在於組織胺H2受體在壁細胞的角色:壁細胞H2受體受刺激會活化cAMP、促進質子幫浦泌酸,Cimetidine競爭性拮抗H2受體,阻斷此路徑而減少胃酸,故選B。A的活化prostaglandin受體是保護黏膜方向,非其機轉。C的拮抗膽鹼M受體是抗膽鹼藥作用。D的抑制質子幫浦是氫離子幫浦抑制劑(如omeprazole)的機轉,作用位在泌酸最終共同路徑,與H2拮抗劑不同。三者皆非其作用點,唯拮抗H2受體為正解。","壁細胞泌酸三刺激:組織胺(H2)、乙醯膽鹼(M3)、gastrin,三者最終匯集到H+\u002FK+-ATPase質子幫浦。H2拮抗劑(cimetidine、ranitidine,字尾-tidine)阻斷組織胺路徑;PPI(-prazole)直接鎖死質子幫浦,抑酸更強更持久。Cimetidine另抑制CYP450易致藥物交互作用,且有抗雄性素作用(男性女乳)。可連結壁細胞泌酸生理、PPI與H2拮抗劑比較複習。",[25,27,30,32],{"term":26,"count":11},"Cimetidine",{"term":28,"count":29},"H2組織胺受體拮抗",1,{"term":31,"count":29},"壁細胞泌酸",{"term":33,"count":29},"質子幫浦",[35,39,44,49,54,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-109-2-basic-medicine-061","下列何種藥物屬於腸刺激或腸興奮劑，常與含有docusate的軟便劑合用，用於治療鴉片類藥物引發之便秘？",61,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-110-1-basic-medicine-077","有關梅毒螺旋菌（Treponema pallidum）的感染，下列敘述何者錯誤？",77,110,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-111-1-basic-medicine-011","下列何者不屬於小腸的一部分？",11,111,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-112-2-basic-medicine-029","食道腺癌（Esophageal Adenocarcinoma）與下列何者的關係最為密切？",29,112,{"webId":55,"stem":56,"number":57,"year":58,"session":59},"nurse-113-3-basic-medicine-033","下列藥物中，何者不作為躁鬱症（mania and bipolar disorder）的治療用藥？",33,113,3,{"webId":61,"stem":62,"number":63,"year":64,"session":29},"nurse-115-1-basic-medicine-027","下列何種病毒不會造成慢性肝炎？",27,115,"2026-09-04",1788510715274]