[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-109-2-basic-medicine-057":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-109-2-基礎醫學-057","nurse-109-2-basic-medicine-057",109,2,57,"Lorcaserin是透過刺激下列何種受體去抑制食慾，而達到減重效果？",{"A":15,"B":16,"C":17,"D":18},"5-HT 1A serotonin receptor","5-HT 1D serotonin receptor","5-HT 2C serotonin receptor","5-HT 4 serotonin receptor","C",null,[],"本題考點在於減重藥Lorcaserin的血清素受體選擇性。考點在於5-HT2C受體對食慾的調控:Lorcaserin選擇性活化下視丘5-HT2C受體,刺激POMC神經元、增加飽足感而抑制食慾,達減重效果,故選C。A的5-HT1A多與焦慮、情緒調節相關。B的5-HT1D與偏頭痛用藥triptan類血管收縮相關。D的5-HT4與腸胃道蠕動促進相關。刻意選5-HT2C的選擇性,正為避開fenfluramine刺激5-HT2B造成心臟瓣膜病變的教訓。三者受體皆非其抑食慾機轉,唯5-HT2C為正解。","Lorcaserin機轉:選擇性5-HT2C→活化下視丘弓狀核POMC神經元→產生α-MSH→作用MC4R→抑制食慾。刻意避開5-HT2B(心臟瓣膜)與5-HT2A(致幻)以提高安全性,這是fen-phen事件後的藥物設計。惟因後續致癌疑慮已於部分市場撤出,考試仍常考其受體。對照:5-HT1D=triptan、5-HT3=止吐ondansetron、5-HT4=促腸蠕動。可連結下視丘食慾調控、血清素受體亞型功能複習。",[25,27,30,32],{"term":26,"count":11},"Lorcaserin",{"term":28,"count":29},"5-HT2C receptor",1,{"term":31,"count":29},"下視丘食慾調控",{"term":33,"count":29},"POMC神經元",[35,39,44,49,54,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-109-2-basic-medicine-058","Amiodarone為治療心室心搏過速，合併左心室功能受損之首選用藥，下列何者不是長期使用此藥後的副作用？",58,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-110-1-basic-medicine-074","五大主要類型的免疫球蛋白（immunoglobulin）具有不同的性質與功能，下列敘述何者正確？",74,110,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-111-1-basic-medicine-008","下列管道何者不開口於右心房？",8,111,{"webId":50,"stem":51,"number":52,"year":53,"session":11},"nurse-112-2-basic-medicine-026","容易引發血管內不正常血栓形成的因素不包括下列何者？",26,112,{"webId":55,"stem":56,"number":57,"year":58,"session":59},"nurse-113-3-basic-medicine-030","甲狀腺乳突癌（papillary carcinoma），下列何者最少見？",30,113,3,{"webId":61,"stem":62,"number":63,"year":64,"session":29},"nurse-115-1-basic-medicine-024","有關流行性感冒病毒（influenza virus），下列敘述何者正確？",24,115,"2026-09-04",1788510715254]