[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-109-2-basic-medicine-052":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-109-2-基礎醫學-052","nurse-109-2-basic-medicine-052",109,2,52,"下列何種抗癌藥物，對細胞周期具有專一性作用？",{"A":15,"B":16,"C":17,"D":18},"Etoposide","Cisplatin","Carmustine","Cyclophosphamide","A",null,[],"本題考點在於抗癌藥對細胞周期的專一性分類。考點在於區分細胞周期專一與非專一藥物:Etoposide抑制拓樸異構酶II,造成DNA雙股斷裂,作用集中於G2\u002FM期,屬細胞周期專一,故選A。B的Cisplatin為鉑類,形成DNA交聯,作用不限特定周期,屬非專一。C的Carmustine為亞硝基脲類烷化劑,同樣作用於各周期。D的Cyclophosphamide為烷化劑,對靜止與分裂細胞皆有作用,屬非專一。三者皆非專一,唯Etoposide因作用於特定週期而具專一性,為正解。","細胞周期專一藥各鎖定階段:S期(抗代謝物如methotrexate、5-FU)、M期(長春花生物鹼、紫杉醇)、G2\u002FM(etoposide拓樸異構酶II抑制)。非專一藥主要是烷化劑與鉑類,對各期與靜止期皆有效,劑量反應呈線性。臨床意義:專一藥採持續輸注或分次給藥以涵蓋更多分裂細胞。記憶「CCS看階段,CCNS看劑量」。可連結細胞週期、抗代謝物與烷化劑機轉複習。",[25,28,29,31],{"term":26,"count":27},"細胞周期專一性",1,{"term":15,"count":27},{"term":30,"count":27},"拓樸異構酶II",{"term":32,"count":27},"烷化劑非專一性",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-109-2-basic-medicine-053","下列何種給藥途徑的生體可用率（bioavailability）最佳？",53,{"webId":39,"stem":40,"number":41,"year":42,"session":27},"nurse-110-1-basic-medicine-069","包氏螺旋體（Borrelia）感染除了萊姆病（Lyme disease）外，主要造成何種人類疾病？",69,110,{"webId":44,"stem":45,"number":46,"year":47,"session":27},"nurse-111-1-basic-medicine-003","內側蹄系（medial lemniscus）與下列何訊息傳遞有關？",3,111,{"webId":49,"stem":50,"number":51,"year":52,"session":11},"nurse-112-2-basic-medicine-021","一位 18 歲男性因四肢水腫而就醫。他被發現有明顯蛋白尿和高血脂，但是腎臟功能和血壓均正常。腎臟切片的光學顯微鏡檢查顯示正常腎小球構造，但電子顯微鏡檢查發現足細胞（podocyte）突起消失。引起此病人水腫的最可能機轉為下列何者？",21,112,{"webId":54,"stem":55,"number":56,"year":57,"session":46},"nurse-113-3-basic-medicine-025","下列為心肌梗塞（myocardial infarction）的病理變化，請依出現的先後時序予以排列：①嗜中性球浸潤（neutrophilicinfiltration） ②吞噬細胞（macrophages）清除死亡的細胞 ③心肌出現凝固性壞死（coagulative necrosis） ④肉芽組織（granulation tissue）出現，並有膠原纖維（collagen）堆積",25,113,{"webId":59,"stem":60,"number":61,"year":62,"session":27},"nurse-115-1-basic-medicine-019","下列何者不具有味蕾？",19,115,"2026-09-04",1788510715207]