[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-109-2-basic-medicine-049":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-109-2-基礎醫學-049","nurse-109-2-basic-medicine-049",109,2,49,"下列何者為大麻之主要成分THC在腦部主要的結合受體？",{"A":15,"B":16,"C":17,"D":18},"Cannabinoid CB 1 受體","多巴胺D 2 受體","血清素5-HT 3 受體","麩胺酸AMPA受體","A",null,[],"本題考點在於大麻活性成分THC的作用受體。考點在於內源性大麻素系統的受體分布:THC是脂溶性成分,主要作用於中樞神經的cannabinoid CB1受體(GPCR),抑制腺苷酸環化酶並調節神經傳導,產生欣快、認知與記憶影響,故選A。B的多巴胺D2受體與精神分裂用藥及帕金森有關,非THC主要標的。C的血清素5-HT3受體與嘔吐反射及止吐劑ondansetron相關。D的麩胺酸AMPA受體是興奮性離子通道型受體,與突觸傳遞及學習有關。三者皆非THC腦部主要結合位,唯CB1受體正確。","內源性大麻素系統:受體CB1(中樞為主,調控神經傳遞)與CB2(免疫細胞為主);內源性配體為anandamide與2-AG。CB1屬Gi\u002Fo偶聯,活化後抑制cAMP、減少神經傳遞物釋放,解釋THC的鎮痛、增食慾與記憶損害。對照:D2為多巴胺、5-HT3為血清素離子通道、AMPA為麩胺酸;各屬不同神經傳遞系統。可連結GPCR訊息傳遞、止吐與食慾調控機轉複習。",[25,28,30,32],{"term":26,"count":27},"THC",1,{"term":29,"count":27},"cannabinoid CB1受體",{"term":31,"count":27},"內源性大麻素系統",{"term":33,"count":27},"GPCR",[35,39,44,48,53,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-109-2-basic-medicine-050","下列抗心律不整的藥物，何者會延長動作電位的間期，且甲狀腺機能異常者需小心使用？",50,{"webId":40,"stem":41,"number":42,"year":43,"session":27},"nurse-110-1-basic-medicine-066","惡性貧血的病因是因為體內產生對抗下列何者的自體抗體？",66,110,{"webId":45,"stem":46,"number":47,"year":43,"session":11},"nurse-110-2-basic-medicine-080","下列何種寄生蟲病診斷時不需要檢查糞便檢體？",80,{"webId":49,"stem":50,"number":51,"year":52,"session":11},"nurse-112-2-basic-medicine-018","尿素和下列那一種物質的累積會造成腎臟髓質組織間的高滲透度（ hyperosmolar medullary renal interstitium）？",18,112,{"webId":54,"stem":55,"number":56,"year":57,"session":58},"nurse-113-3-basic-medicine-022","下列何者不是造成血漿滲透壓下降的原因？",22,113,3,{"webId":60,"stem":61,"number":62,"year":63,"session":27},"nurse-115-1-basic-medicine-016","就多數情況而言，下列有關右肺肋面（costal surface）裂隙的敘述，何者錯誤？",16,115,"2026-09-04",1788510715181]