[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-109-2-basic-medicine-035":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-109-2-基礎醫學-035","nurse-109-2-basic-medicine-035",109,2,35,"性聯無伽瑪球蛋白血症（X-linked agammaglobulinemia）發病的主要原因，下列何者正確？",{"A":15,"B":16,"C":17,"D":18},"前趨B細胞（pre-B cell）不能分化成B細胞","胸腺發育不良（thymic hypoplasia）","腺嘌呤去胺酶（adenine deaminase；ADA）基因突變","第二級MHC（主要組織相容性抗原複合體）分子缺乏","A",null,[],"本題考點是性聯無伽瑪球蛋白血症(Bruton病)的分子病因。依免疫學,此症因X染色體上的BTK基因突變,使B細胞成熟停滯,前趨B細胞(pre-B cell)無法分化為成熟B細胞,導致血中各類免疫球蛋白幾乎全缺、反覆細菌感染,故正解A。B胸腺發育不良對應的是DiGeorge症候群,屬T細胞缺陷。C腺苷去胺酶(ADA)基因突變造成的是嚴重複合型免疫缺乏(SCID),T、B細胞皆受損。D第二型MHC分子缺乏造成裸淋巴球症候群,影響CD4輔助T細胞活化。故選A。","Bruton病:X性聯隱性,幾乎只影響男嬰,約出生6個月後母源抗體消退才發病,表現為反覆化膿性細菌感染(肺炎鏈球菌、嗜血桿菌),淋巴結與扁桃腺因缺B細胞而發育不良。實驗室:B細胞極少、各類Ig皆低,但T細胞正常。治療以定期免疫球蛋白補充。對比免疫缺陷:B細胞缺陷(莢膜菌感染)、T細胞缺陷(病毒黴菌)、SCID(兩者皆缺)、吞噬細胞缺陷(慢性肉芽腫)。記憶:BTK壞→pre-B卡關→無抗體。",[25,28,30,32,34],{"term":26,"count":27},"性聯無伽瑪球蛋白血症",1,{"term":29,"count":27},"BTK基因",{"term":31,"count":27},"pre-B細胞分化障礙",{"term":33,"count":27},"免疫球蛋白缺乏",{"term":35,"count":27},"B細胞缺陷",[37,41,46,50,55,61],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-109-2-basic-medicine-036","下列那一個心臟腔室發生原發性腫瘤的機率最高？",36,{"webId":42,"stem":43,"number":44,"year":45,"session":27},"nurse-110-1-basic-medicine-052","高血壓用藥 furosemide 在分類上屬於下列何者？",52,110,{"webId":47,"stem":48,"number":49,"year":45,"session":11},"nurse-110-2-basic-medicine-066","下列何種補體的成分，可以活化吞噬細胞？",66,{"webId":51,"stem":52,"number":53,"year":54,"session":11},"nurse-112-2-basic-medicine-004","下列何者無法執行閉口的動作？",4,112,{"webId":56,"stem":57,"number":58,"year":59,"session":60},"nurse-113-3-basic-medicine-008","下列有關肝小葉之敘述何者錯誤？",8,113,3,{"webId":62,"stem":63,"number":11,"year":64,"session":27},"nurse-115-1-basic-medicine-002","手舉起椅子一動也不動地罰站，此時維持靜止且正在施力的上臂肌肉之收縮型態為下列何者？",115,"2026-09-04",1788510715044]