[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-109-1-basic-medicine-071":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-109-1-基礎醫學-071","nurse-109-1-basic-medicine-071",109,1,71,"Azole 類抗黴菌劑的作用機轉是：",{"A":15,"B":16,"C":17,"D":18},"抑制細胞膜生成","抑制蛋白質合成","抑制細胞壁生成","抑制核酸合成","A",null,[],"本題考點是 azole 類抗黴菌劑的作用機轉。azole 藥物抑制真菌的 lanosterol 14α-去甲基酶（cytochrome P450 依賴），阻斷 ergosterol 合成，導致細胞膜無法正常生成而功能失常，故其機轉為抑制細胞膜（麥角固醇）生成，選 A。B 抑制蛋白質合成是胺基醣苷或大環內酯類抗菌機轉。C 抑制細胞壁生成是 echinocandins（抑 β-葡聚醣）或抗菌 β-lactam 的機轉。D 抑制核酸合成對應 flucytosine，皆非 azole 途徑。","真菌細胞膜以 ergosterol 為主要固醇（相當於人類的膽固醇）。azole 抑制 14α-demethylase 使 lanosterol 無法轉為 ergosterol，膜結構與通透性受損。抗真菌機轉對照：polyene（amphotericin B）直接結合 ergosterol 打洞；allylamine（terbinafine）抑 squalene epoxidase 也降 ergosterol；echinocandin 抑細胞壁 β-1,3-glucan；flucytosine 干擾核酸。記憶：azole＝抑 ergosterol 合成（膜），不是壁。",[25,27,29,31],{"term":26,"count":11},"Azole 抗黴菌劑機轉",{"term":28,"count":11},"ergosterol 合成抑制",{"term":30,"count":11},"14α-去甲基酶 P450",{"term":32,"count":11},"真菌細胞膜",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-109-1-basic-medicine-072","下列有關中華肝吸蟲（Clonorchis sinensis）之敘述，何者正確？",72,{"webId":39,"stem":40,"number":41,"year":42,"session":11},"nurse-110-1-basic-medicine-008","下列關於內分泌細胞的敘述，何者錯誤？",8,110,{"webId":44,"stem":45,"number":46,"year":42,"session":47},"nurse-110-2-basic-medicine-022","下列何種細胞受損對血腦障壁（blood-brain barrier）的功能影響最大？",22,2,{"webId":49,"stem":50,"number":51,"year":52,"session":11},"nurse-112-1-basic-medicine-010","總膽管是由下列何者會合而形成？",10,112,{"webId":54,"stem":55,"number":56,"year":57,"session":47},"nurse-113-2-basic-medicine-014","下列何種激素的分泌對血糖濃度的影響最小？",14,113,{"webId":59,"stem":60,"number":41,"year":61,"session":62},"nurse-114-3-basic-medicine-008","想要聽清楚主動脈半月瓣（aortic semilunar valve）關閉的心音，要將聽診器置放於何處最佳？",114,3,"2026-09-04",1788510711526]