[{"data":1,"prerenderedAt":63},["ShallowReactive",2],{"q-nurse-109-1-basic-medicine-058":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":62},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-109-1-基礎醫學-058","nurse-109-1-basic-medicine-058",109,1,58,"關節炎之發炎反應可用 celecoxib 加以治療，其較少引發胃腸道出血。此藥物主要阻斷何種自泌素之生合成？",{"A":15,"B":16,"C":17,"D":18},"緩激肽（bradykinin）","前列腺素（prostaglandin）","白三烯素（leukotriene）","組織胺（histamine）","B",null,[],"本題考點是 celecoxib 的作用標靶。celecoxib 屬選擇性 COX-2 抑制劑，COX（cyclooxygenase）是把花生四烯酸轉成前列腺素（prostaglandin）的酵素，故此藥主要阻斷前列腺素之生合成而抗發炎，選 B。它選擇性抑 COX-2 而較不影響護胃的 COX-1 前列腺素，因此腸胃道出血較少，正呼應題幹。A 緩激肽由激肽系統產生，非 COX 產物。C 白三烯素由 lipoxygenase（LOX）路徑生成，非 COX。D 組織胺由肥大細胞經組胺酸去羧生成，與 COX 無關。","花生四烯酸代謝分兩路：COX 路徑生成前列腺素與血栓素，LOX 路徑生成白三烯素。COX-1 為結構型（保護胃黏膜、維持腎血流、促血小板凝集），COX-2 為誘導型（發炎時大量表現）。celecoxib 選擇性抑 COX-2 可保留 COX-1 護胃前列腺素故較少胃出血，代價是打破 PGI2\u002FTXA2 平衡而升心血管風險。對比：傳統 NSAID 兩者皆抑，故胃傷害大。",[25,27,29,31],{"term":26,"count":11},"celecoxib 選擇性 COX-2 抑制",{"term":28,"count":11},"前列腺素生合成",{"term":30,"count":11},"花生四烯酸 COX 路徑",{"term":32,"count":11},"COX-1 護胃作用",[34,38,43,48,53,57],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-109-1-basic-medicine-059","有關抗生素 amoxicillin 之敘述，下列何者錯誤？",59,{"webId":39,"stem":40,"number":41,"year":10,"session":42},"nurse-109-2-basic-medicine-075","下列關於披衣菌（Chlamydiaceae）的敘述，何者正確？",75,2,{"webId":44,"stem":45,"number":46,"year":47,"session":42},"nurse-110-2-basic-medicine-009","下列何者不是皮膚表皮（epidermis）的細胞層？",9,110,{"webId":49,"stem":50,"number":51,"year":52,"session":42},"nurse-111-2-basic-medicine-047","下列何種黴菌常經由呼吸道感染？",47,111,{"webId":54,"stem":55,"number":11,"year":56,"session":42},"nurse-113-2-basic-medicine-001","下列何者能傳遞表皮的觸覺？",113,{"webId":58,"stem":59,"number":60,"year":61,"session":42},"nurse-114-2-basic-medicine-045","金黃色葡萄球菌常在食材煮熟前就污染了食物，因而造成食物中毒。下列針對該菌造成食物中毒的敘述何者錯誤？",45,114,"2026-09-04",1788510711403]