[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-109-1-basic-medicine-054":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-109-1-基礎醫學-054","nurse-109-1-basic-medicine-054",109,1,54,"有關 omalizumab 之敘述，下列何者正確？",{"A":15,"B":16,"C":17,"D":18},"是一種抗體製劑，臨床上用於治療痛風性關節炎（gouty arthritis）","藉由抑制人類免疫球蛋白 G（immunoglobulin G）受體而產生療效","可有效減低發炎介質自肥大細胞（mast cell）釋放的機會","因方便大量製造且價格便宜，故常作為第一線用藥","C",null,[],"本題考點是 omalizumab 的作用機轉。omalizumab 是抗 IgE 的單株抗體，與游離 IgE 的 Fc 段結合，使其無法接上肥大細胞上的 FcεRI 受體，阻斷過敏原引發的去顆粒化，故能減少發炎介質自肥大細胞釋放，選 C。A 錯在它用於中重度過敏性氣喘與慢性蕁麻疹，不是痛風性關節炎。B 錯在它結合的是 IgE 而非抑制 IgG 受體。D 錯在單株抗體製程昂貴、屬生物製劑，並非便宜的第一線用藥，臨床保留給類固醇控制不良者。","omalizumab 結合游離 IgE 的 Cε3 區（正是 IgE 接 FcεRI 的位置），降低血中游離 IgE，並下調肥大細胞與嗜鹼球表面 FcεRI 表現量，形成雙重抑制。適應症：IgE 介導的過敏性氣喘、慢性自發性蕁麻疹。對照記憶：抗 IgE=omalizumab、抗 IL-5=mepolizumab、抗 IL-4\u002F13=dupilumab，皆為氣喘生物製劑但標靶不同。",[25,28,31,33],{"term":26,"count":27},"生物製劑",3,{"term":29,"count":30},"肥大細胞去顆粒化",2,{"term":32,"count":11},"omalizumab 抗 IgE 單株抗體",{"term":34,"count":11},"FcεRI 受體",[36,40,44,49,54,59],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-109-1-basic-medicine-055","使用下列何種藥物，最易導致潛在結核病（latent tuberculosis）復發？",55,{"webId":41,"stem":42,"number":43,"year":10,"session":30},"nurse-109-2-basic-medicine-071","下列疾病何者不屬於自體免疫疾病（autoimmune disease）？",71,{"webId":45,"stem":46,"number":47,"year":48,"session":30},"nurse-110-2-basic-medicine-005","下列何者不通過肺門？",5,110,{"webId":50,"stem":51,"number":52,"year":53,"session":30},"nurse-111-2-basic-medicine-043","關於第 I 類 MHC 分子呈現經由內源性路徑產生的抗原，下列敘述何者正確？",43,111,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-113-1-basic-medicine-047","下列何種細菌感染所造成的腸炎，最可能引發周邊神經病變（Guillain-Barré症候群）？",47,113,{"webId":60,"stem":61,"number":62,"year":63,"session":30},"nurse-114-2-basic-medicine-041","外科手術器材如帶有塑膠材質，下列何者是最適合的消毒法？",41,114,"2026-09-04",1788510711366]