[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-109-1-basic-medicine-052":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":26},"nurse-109-1-基礎醫學-052","nurse-109-1-basic-medicine-052",109,1,52,"下列何種藥物可抑制 tumor tyrosine kinase 活性，因而可用於 chronic myeloid leukemia 及 gastrointestinal stromal tumor？",{"A":15,"B":16,"C":17,"D":18},"Irinotecan","Etoposide","Palcitaxel","Imatinib","D",null,[],"本題考點是酪胺酸激酶抑制劑在標靶治療的應用。Imatinib 抑制 BCR-ABL 及 c-KIT 等酪胺酸激酶活性，用於慢性骨髓性白血病（CML，BCR-ABL 陽性）與胃腸道基質瘤（GIST，c-KIT 突變），故選 D。(A) Irinotecan 為拓樸異構酶 I 抑制劑，非酪胺酸激酶抑制劑。(B) Etoposide 為拓樸異構酶 II 抑制劑，作用機轉不同。(C) Paclitaxel（題目拼作 Palcitaxel）為紫杉醇類、穩定微管抑制細胞分裂，非酪胺酸激酶抑制劑。故抑制酪胺酸激酶者為 Imatinib，答案為 D。","Imatinib（基利克）是里程碑式標靶藥：CML 由費城染色體 t(9;22) 產生 BCR-ABL 融合蛋白（持續活化的酪胺酸激酶），imatinib 佔據其 ATP 結合位而抑制增殖；GIST 多帶 c-KIT（CD117）活化突變，同受抑制。對比化療機轉：拓樸異構酶抑制劑（irinotecan 抑 I、etoposide 抑 II，干擾 DNA 解旋\u002F複製）、微管毒（paclitaxel 穩定微管、vincristine 阻聚合）、烷化劑、抗代謝物。記憶：「-tinib 字尾＝酪胺酸激酶抑制劑」，imatinib 治 CML 與 GIST 是必考代表。",[25,27,29,31,33],{"term":18,"count":26},2,{"term":28,"count":26},"酪胺酸激酶抑制劑",{"term":30,"count":11},"BCR-ABL費城染色體",{"term":32,"count":11},"慢性骨髓性白血病CML",{"term":34,"count":11},"胃腸道基質瘤GIST",[36,40,44,49,54,59],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-109-1-basic-medicine-053","下列何者可用於預防和改善暈車和暈船（motion sickness）作用？",53,{"webId":41,"stem":42,"number":43,"year":10,"session":26},"nurse-109-2-basic-medicine-069","病人4個月前到非洲旅遊，回國後一星期因發燒39℃，疲倦就醫，為證明其是否感染惡性瘧疾（Plasmodium falciparum），應收集什麼檢體做鏡檢最適當？",69,{"webId":45,"stem":46,"number":47,"year":48,"session":26},"nurse-110-2-basic-medicine-003","下列何者藉由跟腱（Achilles tendon）附著於跟骨？",3,110,{"webId":50,"stem":51,"number":52,"year":53,"session":26},"nurse-111-2-basic-medicine-041","下列那一種作用過程，不能用來傳遞細菌的遺傳物質？",41,111,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-113-1-basic-medicine-045","治療金黃色葡萄球菌造成的院內感染，下列何種抗生素最可能有效？",45,113,{"webId":60,"stem":61,"number":62,"year":63,"session":26},"nurse-114-2-basic-medicine-039","下列何者不是使用 Corticosteroids 藥物治療時常見之副作用？",39,114,"2026-09-04",1788510711358]