[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-108-2-basic-medicine-056":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-2-基礎醫學-056","nurse-108-2-basic-medicine-056",108,2,56,"有關治療肺結核藥物 isoniazid 的藥理作用相關敘述，下列何者錯誤？",{"A":15,"B":16,"C":17,"D":18},"干擾分枝桿菌蛋白質生合成","可能的副作用為肝毒性與周邊神經病變","主要藉由肝臟代謝","為第一線肺結核治療的四藥策略之一（four-drug regimen）","A",null,[],"本題考點在抗結核藥isoniazid的作用機轉與特性。依藥理學，isoniazid的殺菌機轉是抑制分枝桿菌細胞壁重要成分黴菌酸（mycolic acid）的合成，而非干擾蛋白質生合成，故A敘述錯誤，為本題答案。B正確：常見副作用為肝毒性與周邊神經病變（與維生素B6耗損有關）。C正確：主要經肝臟乙醯化代謝。D正確：isoniazid為第一線抗結核四藥療法（與rifampin、pyrazinamide、ethambutol合用）之一。","isoniazid為前驅藥，需經結核菌的KatG酵素活化後才抑制黴菌酸合成，KatG突變是抗藥性來源。周邊神經病變機轉是INH與維生素B6結構相似而增加其排出，故常併用pyridoxine（B6）預防。乙醯化速率有基因多型性，慢乙醯化者藥物濃度高、副作用風險增。記憶口訣：INH打『細胞壁黴菌酸』，不是打蛋白質；配B6防神經病變。可連結：黴菌酸合成、KatG活化、pyridoxine預防、四藥抗結核療法（RIPE）。",[25,28,30,32],{"term":26,"count":27},"isoniazid抑制黴菌酸合成",1,{"term":29,"count":27},"非抑制蛋白質合成",{"term":31,"count":27},"肝毒性與周邊神經病變",{"term":33,"count":27},"四藥抗結核療法",[35,39,44,49,54,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-108-2-basic-medicine-057","在藥物作用於受體層次上，重複給予下列何者藥物，不會造成 β-腎上腺素受體去敏感性？",57,{"webId":40,"stem":41,"number":42,"year":43,"session":27},"nurse-109-1-basic-medicine-073","下列何者不是病毒外套膜（envelope）的特性？",73,109,{"webId":45,"stem":46,"number":47,"year":48,"session":27},"nurse-110-1-basic-medicine-007","下列何者位於延髓（medulla oblongata）？",7,110,{"webId":50,"stem":51,"number":52,"year":53,"session":27},"nurse-111-1-basic-medicine-045","下列何者與新生兒呼吸窘迫症候群最不相關？",45,111,{"webId":55,"stem":56,"number":57,"year":58,"session":59},"nurse-112-3-basic-medicine-019","下列何者屬於腸道神經系統（enteric nervous system）？",19,112,3,{"webId":61,"stem":62,"number":63,"year":64,"session":27},"nurse-114-1-basic-medicine-013","下列有關成人腰椎（lumbar vertebrae）的敘述，何者正確？",13,114,"2026-09-04",1788510705300]