[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-108-2-basic-medicine-053":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-2-基礎醫學-053","nurse-108-2-basic-medicine-053",108,2,53,"每天服用一次低劑量（80～120 mg）的阿斯匹林（aspirin），可降低動脈血栓發生的機率，此作用是抑制體內何種物質的生合成？",{"A":15,"B":16,"C":17,"D":18},"thromboxane A 2","prostacyclin","leukotrienes","angiotensin II","A",null,[],"本題考點在低劑量阿斯匹林抗血栓的分子機轉。依藥理學，阿斯匹林不可逆抑制環氧化酶（COX），低劑量選擇性抑制血小板內COX-1，減少血栓素A2（thromboxane A2）生合成，因血小板無細胞核無法再合成酵素，作用可持續至血小板生命週期結束，故降低動脈血栓，選A。B的prostacyclin（PGI2）具抗血小板作用，抑制它反而不利。C的leukotrienes經脂氧合酶途徑生成，與COX無關。D的angiotensin II屬腎素-血管收縮素系統，非阿斯匹林標的。","低劑量阿斯匹林的巧妙在『不對稱抑制』：血小板無核，被不可逆抑制後整個生命週期都做不出TXA2；血管內皮有核，能重新合成COX與抗血小板的prostacyclin，故淨效果偏向抗血栓。TXA2促血小板聚集與血管收縮，PGI2作用相反，兩者拮抗維持平衡。記憶口訣：低劑量『壓壞沒核的血小板、放過有核的內皮』。可連結：COX-1不可逆抑制、血栓素A2 vs prostacyclin、血小板無核、脂氧合酶白三烯途徑。",[25,28,30,32],{"term":26,"count":27},"阿斯匹林不可逆抑制COX-1",1,{"term":29,"count":27},"血栓素A2生合成",{"term":31,"count":27},"血小板無核",{"term":33,"count":27},"prostacyclin抗血小板對比",[35,39,44,49,54,60],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-108-2-basic-medicine-054","下列何種藥物可減少糖分的吸收？",54,{"webId":40,"stem":41,"number":42,"year":43,"session":27},"nurse-109-1-basic-medicine-070","下列細胞何者通常不具抗原呈現細胞（Antigen-presenting cell）之功能？",70,109,{"webId":45,"stem":46,"number":47,"year":48,"session":27},"nurse-110-1-basic-medicine-004","關於心臟腔室的敘述，下列何者錯誤？",4,110,{"webId":50,"stem":51,"number":52,"year":53,"session":27},"nurse-111-1-basic-medicine-042","肝臟因為慢性右側心臟衰竭發生嚴重充血現象時，肝小葉中心區域出現出血性壞死，稱為：",42,111,{"webId":55,"stem":56,"number":57,"year":58,"session":59},"nurse-112-3-basic-medicine-016","下列何種變化最有利於增加骨質密度？",16,112,3,{"webId":61,"stem":62,"number":63,"year":64,"session":27},"nurse-114-1-basic-medicine-010","有關輔脂解酶（colipase）的敘述，下列何者正確？",10,114,"2026-09-04",1788510705272]