[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-108-2-basic-medicine-051":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-2-基礎醫學-051","nurse-108-2-basic-medicine-051",108,2,51,"下列安眠藥中，何者不具有抗痙攣或肌肉鬆弛之特性，且長期使用較不易產生耐受性（tolerance）？",{"A":15,"B":16,"C":17,"D":18},"eszopiclone","ramelteon","hydroxyzine","zolpidem","D",null,[],"本題考點在安眠藥依作用受體選擇性所致的藥理差異。依藥理學，zolpidem屬非苯二氮平類（Z-drug），選擇性作用於GABA-A受體含α1次單元的BZ1（ω1）位置，故主要產生鎮靜安眠，而較少抗痙攣或肌肉鬆弛作用，且相對較不易產生耐受性，故選D。A的eszopiclone與D同屬Z-drug但本題取zolpidem為典型。B的ramelteon為褪黑激素受體致效劑，機轉不同。C的hydroxyzine為抗組織胺類鎮靜劑，皆非本題指向的BZ1選擇性作用。","傳統苯二氮平類非選擇性作用於GABA-A各α次單元，故兼具抗焦慮、抗痙攣、肌肉鬆弛與安眠，也較易耐受與依賴。Z-drug（zolpidem等）對α1（BZ1\u002Fω1）較選擇，安眠效果保留、其他作用與耐受性相對減少。記憶口訣：α1管『睡』、α2管『抗焦慮\u002F肌鬆』；Z-drug專打α1所以較純安眠。本題為選擇題語意上取zolpidem，掌握BZ1選擇性即可。可連結：GABA-A次單元、BZ1\u002Fω1受體、Z-drug、耐受性與依賴。",[25,28,30,32],{"term":26,"count":27},"zolpidem為Z-drug",1,{"term":29,"count":27},"GABA-A受體α1\u002FBZ1選擇性",{"term":31,"count":27},"苯二氮平非選擇性作用",{"term":33,"count":27},"耐受性差異",[35,39,44,48,53,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-108-2-basic-medicine-052","有關 H 1 組織胺受體拮抗藥物（anti-histamine）的治療用途，下列何者錯誤？",52,{"webId":40,"stem":41,"number":42,"year":43,"session":27},"nurse-109-1-basic-medicine-068","下列針對 Bacillus cereus 造成的疾病，何者正確？",68,109,{"webId":45,"stem":46,"number":11,"year":47,"session":27},"nurse-110-1-basic-medicine-002","下列椎骨中，何者的棘突（spinous process）最長？",110,{"webId":49,"stem":50,"number":51,"year":52,"session":27},"nurse-111-1-basic-medicine-040","子宮頸癌最可能與何者病毒感染有關？",40,111,{"webId":54,"stem":55,"number":56,"year":57,"session":58},"nurse-112-3-basic-medicine-014","下列何者與行為動機（motivation）和獎賞（reward）路徑最為相關？",14,112,3,{"webId":60,"stem":61,"number":62,"year":63,"session":27},"nurse-114-1-basic-medicine-008","正常情況下，下列何種物質在腎臟再吸收（reabsorption）的比例最高？",8,114,"2026-09-04",1788510705250]