[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-108-2-basic-medicine-039":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-108-2-基礎醫學-039","nurse-108-2-basic-medicine-039",108,2,39,"下列何者是濾泡性淋巴瘤（follicular lymphoma）最常見到的染色體變化？",{"A":15,"B":16,"C":17,"D":18},"t（14,18）","t（15,17）","t（11,22）","t（4,11）","A",null,[],"本題考點在濾泡性淋巴瘤的特徵性染色體轉位。依分子病理學，濾泡性淋巴瘤最常見t(14;18)轉位，使第18號染色體上的BCL2基因併到第14號的免疫球蛋白重鏈調控區，導致BCL2過度表現、抑制細胞凋亡而使B細胞存活堆積，故選A。B的t(15;17)為急性前骨髓細胞白血病（APL，PML-RARA）。C的t(11;22)為尤文氏肉瘤（EWS-FLI1）。D的t(4;11)與嬰兒型急性淋巴母細胞白血病（MLL重組）相關，皆非濾泡性淋巴瘤的標誌。","t(14;18)使BCL2失去正常凋亡調控，抗凋亡蛋白過量讓細胞『不該活卻繼續活』，是濾泡性淋巴瘤惰性但難根治的分子基礎。記憶配對表：濾泡性淋巴瘤—t(14;18)—BCL2；APL—t(15;17)—PML-RARA（可用A酸治療）；Burkitt—t(8;14)—MYC；CML—t(9;22)費城染色體—BCR-ABL。可連結：BCL2抗凋亡、免疫球蛋白重鏈啟動子、惰性淋巴瘤、凋亡失調。",[25,27,30,32],{"term":26,"count":11},"濾泡性淋巴瘤",{"term":28,"count":29},"t(14;18)轉位",1,{"term":31,"count":29},"BCL2過度表現",{"term":33,"count":29},"凋亡抑制",[35,39,44,48,53,58],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-108-2-basic-medicine-040","下列何者不是痔瘡發生常見的原因？",40,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-109-1-basic-medicine-056","Beta 腎上腺素受體拮抗劑用於治療心絞痛的藥理作用，不包括下列何者？",56,109,{"webId":45,"stem":46,"number":47,"year":43,"session":11},"nurse-109-2-basic-medicine-070","有關抗菌和滅菌處理的敘述，下列何者錯誤？",70,{"webId":49,"stem":50,"number":51,"year":52,"session":29},"nurse-111-1-basic-medicine-028","下列有關色盲（color blindness）的敘述，何者正確？",28,111,{"webId":54,"stem":55,"number":11,"year":56,"session":57},"nurse-112-3-basic-medicine-002","下列那一種胞器負責分類、包裝並運送蛋白質與脂質？",112,3,{"webId":59,"stem":60,"number":61,"year":62,"session":57},"nurse-113-3-basic-medicine-046","肝炎病毒中，那一種病毒需要 B 型肝炎病毒同時感染，才能幫助它複製繁殖？",46,113,"2026-09-04",1788510705134]