[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-108-2-basic-medicine-023":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-2-基礎醫學-023","nurse-108-2-basic-medicine-023",108,2,23,"下列何種激素由腺體分泌後，可被轉變為更具活性的形式？",{"A":15,"B":16,"C":17,"D":18},"三碘甲狀腺素（triiodothyronine, T 3 ）","逆三碘甲狀腺素（reverse triiodothyronine, rT 3 ）","血管張力素 II（angiotensin II）","睪固酮（testosterone）","D",null,[],"本題考點為激素分泌後需再經活化的類型。睪固酮分泌後,在標的組織可經5α還原酶轉化為活性更強的雙氫睪固酮(DHT),屬分泌後才轉為更具活性形式的激素,故選D。A三碘甲狀腺素(T3)本身即是甲狀腺激素的活性型,不需再活化,反而是由T4去碘活化而來。B逆三碘甲狀腺素(rT3)是無活性的產物,並非更具活性。C血管張力素II已是該系統的活性終產物,由血管張力素I經ACE轉化而來,不再向上活化。判斷關鍵在於認清睪固酮在周邊組織活化為DHT的機轉,其餘選項或已是活性型、或為無活性代謝物。","激素活化的兩種型態:T4在周邊經去碘酶轉為活性更高的T3;睪固酮在攝護腺、毛囊等組織經5α還原酶轉為DHT,親和力更高。DHT主導男性外生殖器發育、攝護腺增生與雄性禿。臨床連結:5α還原酶抑制劑(finasteride)減少DHT生成,用於良性攝護腺肥大與雄性禿。對比:rT3為T4去碘的無活性支路,壓力或飢餓時rT3↑以節能。記憶:「睪固酮到DHT、T4到T3,都是愈變愈強」。",[25,28,31,33],{"term":26,"count":27},"睪固酮",5,{"term":29,"count":30},"雙氫睪固酮DHT",1,{"term":32,"count":30},"5α還原酶",{"term":34,"count":30},"激素周邊活化",[36,40,45,49,54,59],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-108-2-basic-medicine-024","一位 50 歲女性有低血鈣、高血磷與低尿磷等症狀，注射副甲狀腺素（PTH）治療會增加尿液中 cAMP 的濃度，此女士可能罹患下列何種疾病？",24,{"webId":41,"stem":42,"number":43,"year":44,"session":30},"nurse-109-1-basic-medicine-040","一位中年男性於月前發生腦梗塞後，醫師在後續電腦斷層掃描檢查時，在皮質部發現一個囊狀的區域，這個變化最可能造成原因是腦組織發生：",40,109,{"webId":46,"stem":47,"number":48,"year":44,"session":11},"nurse-109-2-basic-medicine-054","下列何種擬交感神經作用劑（sympathomimetics）可散瞳，用於眼底檢查？",54,{"webId":50,"stem":51,"number":52,"year":53,"session":30},"nurse-111-1-basic-medicine-012","下列何者位於肝臟尾葉（caudate lobe）的右側？",12,111,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-112-2-basic-medicine-036","下列降血脂藥物中，何者可使脂肪組織血管內之脂蛋白脂解酶（lipoprotein lipase）生成量增加，而使血中三酸甘油脂濃度降低，主要用於治療高三酸甘油脂血症（hypertriglyceridemia）？",36,112,{"webId":60,"stem":61,"number":62,"year":63,"session":64},"nurse-113-3-basic-medicine-030","甲狀腺乳突癌（papillary carcinoma），下列何者最少見？",30,113,3,"2026-09-04",1788510704981]