[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-108-1-basic-medicine-074":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-1-基礎醫學-074","nurse-108-1-basic-medicine-074",108,1,74,"T 細胞與 B 細胞的交互作用能增強宿主對抗微生物的防禦。下列何者不需要 T 細胞的參與？",{"A":15,"B":16,"C":17,"D":18},"B 細胞從產生 IgM 的反應轉變成 IgG","對細菌夾膜多醣快速產生抗體反應","刺激 B 細胞的增殖與分化","引起續發性、加強抗體反應","B",null,[],"本題考點在 T 細胞依賴與非依賴性抗原的抗體反應。對細菌莢膜多醣這類多醣抗原，B 細胞可經多價交聯直接產生快速的 IgM 反應，不需 T 細胞輔助，屬 T 細胞非依賴性抗原，故選 B。A 抗體類型由 IgM 轉換為 IgG 的類別轉換需 T 細胞提供 CD40L 與細胞激素訊號。C 刺激 B 細胞增殖分化多需 T 輔助訊號。D 續發性、加強型記憶抗體反應同樣仰賴 T 細胞協助建立記憶，故三者皆需 T 細胞參與，唯莢膜多醣的快速抗體不需。","抗原分兩類：T 依賴性（蛋白質，需 Th 提供 CD40L 與 IL-4\u002F21 等訊號，才能類別轉換、親和力成熟並形成記憶 B 細胞）與 T 非依賴性（如多醣、脂多醣，可多價交聯 BCR 直接刺激，主要產生 IgM、記憶差）。此原理解釋幼兒對純多醣疫苗反應弱，故將多醣『接合』蛋白質載體製成接合型疫苗（如 Hib、肺炎鏈球菌接合疫苗），把 T 非依賴抗原轉為 T 依賴，誘發較佳的 IgG 與記憶反應。",[25,28,30,32,34],{"term":26,"count":27},"T 輔助細胞",2,{"term":29,"count":11},"T 細胞非依賴性抗原",{"term":31,"count":11},"莢膜多醣",{"term":33,"count":11},"抗體類別轉換",{"term":35,"count":11},"接合型疫苗原理",[37,41,46,50,55,60],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-108-1-basic-medicine-075","下列何者與 CD8 T 細胞的作用較無關？",75,{"webId":42,"stem":43,"number":44,"year":45,"session":11},"nurse-109-1-basic-medicine-011","下列何者是由入球小動脈（afferent arteriole）的管壁平滑肌細胞特化形成，能分泌腎活素（renin）調節血壓？",11,109,{"webId":47,"stem":48,"number":49,"year":45,"session":27},"nurse-109-2-basic-medicine-025","下列何種激素的作用，最可能抑制個體生長？",25,{"webId":51,"stem":52,"number":53,"year":54,"session":27},"nurse-110-2-basic-medicine-063","下列何種藥物可以治療免疫不全病人，因感染巨細胞病毒（CMV）導致視網膜炎，以及對 acyclovir 無效之單純疱疹病毒感染？",63,110,{"webId":56,"stem":57,"number":58,"year":59,"session":27},"nurse-112-2-basic-medicine-007","子宮的那一部分直接與陰道（vagina）相接，可以藉由陰道擴張器（vaginal dilator）直接觀察檢測？",7,112,{"webId":61,"stem":62,"number":11,"year":63,"session":64},"nurse-113-3-basic-medicine-001","大轉子（greater trochanter）位於下列那塊骨骼？",113,3,"2026-09-04",1788510708712]