[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-108-1-basic-medicine-065":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-1-基礎醫學-065","nurse-108-1-basic-medicine-065",108,1,65,"蛋白質感染原（prion）是非微生物性的病原體，下列敘述何者正確？",{"A":15,"B":16,"C":17,"D":18},"患者腦部成海綿狀空泡化","患者有強烈的發炎反應，會有發燒現象","致病原可用一般消毒滅菌方法將之殺死","患者會產生抗體等免疫反應","A",null,[],"本題考點在蛋白質感染原（prion）的病理與抗性特性。Prion 是異常摺疊的蛋白質，會誘導正常 PrP 蛋白轉為病態構型堆積於腦部，使神經元退化、腦組織呈海綿狀空泡化，故選 A。B 稱有強烈發炎與發燒，prion 病不引起典型發炎反應，屬無炎性退化性病變，敘述錯誤。C 稱可用一般消毒滅菌殺死，prion 對高溫、輻射、甲醛、常規高壓滅菌具高度抗性，需特殊去污程序，敘述錯誤。D 稱會產生抗體等免疫反應，prion 為自身蛋白構型改變，不引發專一性抗體或免疫反應，故不選。","Prion 病（傳染性海綿狀腦病）包含庫賈氏症（CJD）、庫魯症、牛海綿狀腦病（狂牛症）。核心機轉：正常 PrPᶜ（α-螺旋為主）被病態 PrPˢᶜ（β-摺疊為主）誘導轉型、抗蛋白酶分解而堆積成斑塊，導致海綿狀退化。特徵記憶：無核酸、無發炎、無發燒、無抗體、對常規消毒與蛋白酶抗性強，滅活需高濃度 NaOH 或延長高溫高壓。臨床表現為快速進行的失智、肌陣攣與共濟失調。",[25,28,30,32,34],{"term":26,"count":27},"海綿狀腦病變",4,{"term":29,"count":11},"蛋白質感染原 prion",{"term":31,"count":11},"PrP 異常摺疊",{"term":33,"count":11},"消毒抗性",{"term":35,"count":11},"無免疫反應",[37,41,46,50,55,60],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-108-1-basic-medicine-066","下列自體免疫疾病中，何者為自體抗體模擬特定分子結合在受體上導致細胞活化及增生，而非造成該細胞的破壞及死亡？",66,{"webId":42,"stem":43,"number":44,"year":45,"session":11},"nurse-109-1-basic-medicine-002","下列胞器中，何者負責製造 ATP？",2,109,{"webId":47,"stem":48,"number":49,"year":45,"session":44},"nurse-109-2-basic-medicine-016","交感神經中的大內臟神經（greater splanchnic nerve）其節前神經纖維來自下列何者？",16,{"webId":51,"stem":52,"number":53,"year":54,"session":44},"nurse-110-2-basic-medicine-054","如果一個藥物的半衰期為 10 小時，以靜脈輸注此藥物後，在血液中達到穩定濃度所需的時間約多久？",54,110,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-112-1-basic-medicine-048","小兒麻痺病毒（polio virus）所引起的小兒麻痺曾經使人類引以為懼，但自有了疫苗後，對人類的威脅大為減低，對這二個疫苗，下列敘述何者正確？",48,112,{"webId":61,"stem":62,"number":63,"year":64,"session":44},"nurse-113-2-basic-medicine-042","對抗病菌後死亡的嗜中性白血球（neutrophil），會由何種細胞清除，以維持組織恆定？",42,113,"2026-09-04",1788510708643]