[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-108-1-basic-medicine-062":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-108-1-基礎醫學-062","nurse-108-1-basic-medicine-062",108,1,62,"下列何種藥物，是藉由活化氯離子通道而增加腸道液體的釋放，用於治療慢性便祕？",{"A":15,"B":16,"C":17,"D":18},"Glycerin suppositories","Mineral oil","Lubiprostone","Aluminum hydroxide","C",null,[],"本題考點在便祕用藥中『活化氯離子通道』的分泌型瀉劑。依機轉，活化腸道上皮 type-2 氯離子通道（ClC-2）會促進氯與水分泌入腸腔、軟化糞便，符合者為 C Lubiprostone，用於慢性便祕與腸躁症便祕型。A 甘油栓劑靠滲透與局部刺激直腸反射排便，非氯通道機轉。B 礦物油（mineral oil）為潤滑性瀉劑，包覆糞便減少水分吸收，機轉不同。D 氫氧化鋁為制酸劑，含鋁反而造成便祕，並非瀉劑，故皆不選。","瀉劑分類對比記憶：膨脹型（psyllium）、滲透型（乳果糖、聚乙二醇、鎂鹽）、刺激型（Bisacodyl、Senna）、潤滑型（mineral oil）、分泌促進型（Lubiprostone 活化 ClC-2；Linaclotide 活化鳥苷酸環化酶 C 增加 cGMP → CFTR 分泌）。Lubiprostone 為前列腺素 E₁ 衍生物但主要透過氯通道而非典型前列腺素受體發揮作用，常見副作用為噁心。制酸劑選擇上，含鋁易便祕、含鎂易腹瀉，臨床常合併以互相抵消。",[25,26,28,30,32],{"term":17,"count":11},{"term":27,"count":11},"氯離子通道 ClC-2",{"term":29,"count":11},"分泌型瀉劑",{"term":31,"count":11},"慢性便祕",{"term":33,"count":11},"瀉劑分類",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-108-1-basic-medicine-063","關於腸泌素類似物（incretin minetics）的敘述，下列何者錯誤？",63,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-108-2-basic-medicine-079","下列何種真菌感染，不建議以氟康唑（fluconazole）來治療？",79,2,{"webId":45,"stem":46,"number":47,"year":48,"session":43},"nurse-109-2-basic-medicine-013","膽汁之製造及注入消化道的位置，下列何者正確？",13,109,{"webId":50,"stem":51,"number":52,"year":53,"session":43},"nurse-110-2-basic-medicine-051","治療糖尿病的用藥中，下列何者的主要作用是刺激胰臟β細胞釋放insulin？",51,110,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-112-1-basic-medicine-045","法蘭西氏土倫桿菌（Francisella tularensis）主要感染何種人體細胞？",45,112,{"webId":60,"stem":61,"number":62,"year":63,"session":43},"nurse-113-2-basic-medicine-039","下列抗癌藥物中，何者最易產生腎毒性？",39,113,"2026-09-04",1788510708626]